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To address these issues, a responsive coating on Ti surface is constructed, which achieves enhanced osseointegration and infection elimination by on\u2010demand release of therapeutic gas hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) and antibiotic. TiO<jats:sub>2<\/jats:sub> nanotubes (TNT) are anodized on the Ti surface to enhance its bioactivity and serve as reservoirs for the antibiotic. An infection microenvironment\u2010responsive macromolecular H<jats:sub>2<\/jats:sub>S donor layer is coated on top of TNT to inhibit premature leakage of antibiotic. This layer exhibits a sustained release of low\u2010dosage H<jats:sub>2<\/jats:sub>S, which is capable of promoting the osteogenic differentiation and migration of cells. Moreover, the compactness of the macromolecular H<jats:sub>2<\/jats:sub>S donor layer could be broken by bacterial invasion, leading to rapid antibiotic release thus preventing infection. In vitro antibacterial experiments validates significant antibacterial activity of the coating against both Gram\u2010negative (<jats:italic>Escherichia coli<\/jats:italic>) and Gram\u2010positive bacteria (<jats:italic>Staphylococcus aureus<\/jats:italic>). 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