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The extension of CAR\u2010T cell therapy to solid tumors, however, is impeded by several challenges: The absence of tumor\u2010specific antigens, antigen heterogeneity, a complex immunosuppressive tumor microenvironment, and physical barriers to cell infiltration. Additionally, limitations in CAR\u2010T cell manufacturing capacity and the high costs associated with these therapies restrict their widespread application. The integration of nanomaterials into CAR\u2010T cell production and application offers a promising avenue to mitigate these challenges. Utilizing nanomaterials in the production of CAR\u2010T cells can decrease product variability and lower production expenses, positively impacting the targeting and persistence of CAR\u2010T cells in treatment and minimizing adverse effects. This review comprehensively evaluates the use of various nanomaterials in the production of CAR\u2010T cells, genetic modification, and in vivo delivery. 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