{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:47:12Z","timestamp":1787312832871,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100025282","name":"Science, Mathematics, And Research For Transformation Scholarship Program","doi-asserted-by":"publisher","award":["S10OD012301"],"award-info":[{"award-number":["S10OD012301"]}],"id":[{"id":"10.13039\/100025282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The tumor uptake of large non\u2010targeted nanocarriers primarily occurs through passive extravasation, known as the enhanced permeability and retention (EPR) effect. Prior studies demonstrated improved tumor uptake and retention of 4\u2010arm 40 kDa star polyethylene glycol (StarPEG) polymers for cancer imaging by adding prostate\u2010specific membrane antigen (PSMA) targeting small molecule ligands. To test PSMA\u2010targeted delivery and therapeutic efficacy, StarPEG nanodrugs with\/without three copies of PSMA\u2010targeting ligands, ACUPA, are designed and synthesized. For single\u2010photon emission computed tomography (SPECT) imaging and therapy, each nanocarrier is labeled with 177Lu using DOTA radiometal chelator. The radiolabeled nanodrugs, [177Lu]PEG\u2010(DOTA)1 and [177Lu]PEG\u2010(DOTA)1(ACUPA)3, are evaluated in vitro and in vivo using PSMA+ PC3\u2010Pip and\/or PSMA\u2013 PC3\u2010Flu cell lines, subcutaneous xenografts and disseminated metastatic models. The nanocarriers are efficiently radiolabeled with 177Lu with molar activities 10.8\u201315.8 MBq\/nmol. Besides excellent in vitro PSMA binding affinity (kD = 51.7\u00a0nM), the targeted nanocarrier, [177Lu]PEG\u2010(DOTA)1(ACUPA)3, demonstrated excellent in vivo SPECT imaging contrast with 21.3% ID\/g PC3\u2010Pip tumors uptake at 192\u00a0h. Single doses of 18.5\u00a0MBq [177Lu]PEG\u2010(DOTA)1(ACUPA)3 showed complete resolution of the PC3\u2010Pip xenografts observed up to 138\u00a0days. Along with PSMA\u2010targeted excellent imaging contrast, these results demonstrated high treatment efficacy of [177Lu]PEG\u2010(DOTA)1(ACUPA)3 for prostate cancer, with potential for clinical translation.<\/jats:p>","DOI":"10.1002\/adhm.202304618","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:55:59Z","timestamp":1714730159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prostate\u2010Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-3712","authenticated-orcid":false,"given":"Niranjan","family":"Meher","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California  San Francisco CA 94143 USA"},{"name":"National Institute of Pharmaceutical Education and Research Raebareli  Lucknow UP 226002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Ashley","sequence":"additional","affiliation":[{"name":"ProLynx Inc.  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