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Here, an injectable self\u2010healing hydrogel of oxidized konjac glucomannan\/arginine\u2010modified chitosan (OKGM\/CS\u2010Arg, OC) integrated with protocatechualdehyde\u2010@Fe (PF) nanoparticles capable of effectively absorbing near\u2010infrared radiation is synthesized successfully. The OC\/PF hydrogels exhibit excellent mechanical properties, biocompatibility, and antioxidant activity. Moreover, in synergy with PTT, OC\/PF demonstrates potent antibacterial effects while concurrently stimulating cell migration and new blood vessel formation. In methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>\u2010infected full\u2010thickness mouse wounds, the OC\/PF hydrogel displays remarkable antibacterial and anti\u2010inflammatory activities, and accelerates wound healing by regulating the wound immune microenvironment and promoting M2 macrophage polarization. Consequently, the OC\/PF hydrogel represents a novel therapeutic approach for treating multidrug\u2010resistant bacterial infections and offers a technologically advanced solution for managing infectious wounds in clinical settings.<\/jats:p>","DOI":"10.1002\/adhm.202400003","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:55:14Z","timestamp":1715046914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["An Immune\u2010Regulating Polysaccharide Hybrid Hydrogel with Mild Photothermal Effect and Anti\u2010Inflammatory for Accelerating Infected Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"ShengZhe","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. 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