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Combination of antiangiogenesis and immunotherapy holds promise for effective inhibition of tumor proliferation and invasion, while it remains challenging for specific targeting drug delivery to tumors and metastatic lesions. Here, a multifunctional biomimetic liposome loading Gambogic acid (G\/R\u2010MLP) is developed using Ginsenoside Rg3 (Rg3) to substitute cholesterol and cancer cell membrane coating, which is designed to increase long\u2010circulating action by a low immunogenicity and specifically deliver gambogic acid (GA) to tumor site and metastatic lesions by homologous targeting and glucose transporter targeting. After G\/R\u2010MLP accumulates in the primary tumors and metastatic nodules, it synergistically enhances the antitumor efficacy of GA, effectively suppressing the tumor growth and lung metastasis by killing tumor cells, inhibiting tumor cell migration and invasion, achieving antiangiogenesis and improving the antitumor immunity. All in all, the strategy combining chemotherapy, antiangiogenesis, and immunotherapy improves therapeutic efficiency and prolonged survival, providing a new perspective for the clinical treatment of TNBC.<\/jats:p>","DOI":"10.1002\/adhm.202400046","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T10:24:41Z","timestamp":1716200681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Multifunctional Biomimetic Liposomes with Improved Tumor\u2010Targeting for TNBC Treatment by Combination of Chemotherapy, Antiangiogenesis and Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Jinshuai","family":"Lan","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"},{"name":"The MOE Innovation Centre for Basic Medicine Research on Qi\u2010Blood TCM Theories Shanghai University of Traditional 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