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To address these issues, thymoquinone\u2010reinforced injectable and thermosensitive TQ@PEG\u2010PAF\u2010Cur hydrogels with dual functions of microenvironment reshaping and photodynamic therapy are developed. The hydrogel comprises natural compound thymoquinone (TQ) and poly (ethylene glycol)\u2010block\u2010poly (alanine\u2010co\u2010phenyl alanine) copolymers (PEG\u2010PAF) conjugated with natural photosensitizer curcumin (Cur). The incorporation of TQ and Cur reduces the sol\u2010to\u2010gel transition temperature of TQ@PEG\u2010PAF\u2010Cur to 30\u00b0C, compared to PEG\u2010PAF hydrogel (37\u00b0C), due to the formation of strong hydrogen bonding, matching the wound microenvironment temperature. Under blue light excitation, TQ@PEG\u2010PAF\u2010Cur generates significant amounts of reactive oxygen species such as H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, 1O<jats:sub>2<\/jats:sub>, and \u00b7OH, exhibiting rapid and efficient bactericidal capacities against methicillin\u2010resistant Staphylococcus aureus and broad spectrum \u03b2\u2010lactamases Escherichia coli via photodynamic therapy (PDT). Additionally, Cur effectively inhibits the expressions of proinflammatory cytokines in skin tissue\u2010forming cells. As a result, the composite hydrogel can rapidly transform into a gel to cover the wound, reshape the wound microenvironment, and accelerate wound healing in vivo. This collaborative antibacterial strategy provides valuable insights to guide the development of multifunctional materials for efficient wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202400049","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T12:53:35Z","timestamp":1709124815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Herbal Products\u2010Powered Thermosensitive Hydrogel with Phototherapy and Microenvironment Reconstruction for Accelerating Multidrug\u2010Resistant Bacteria\u2010Infected Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Gang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200240 P. R. 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