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Prosthodontic overdentures, commonly used to restore masticatory functions, can cause localized ischemia and inflammation as they often compress patients\u2019 oral mucosa and impede local circulation. This biomechanical stimulus in mucosa is found to accelerate the self\u2010regulated residual ridge resorption (RRR), posing ongoing clinical challenges. Based on the dedicated long\u2010term clinical datasets, this work develops an in\u2010silico framework with a combination of techniques, including advanced image post\u2010processing, patient\u2010specific finite element models and unsupervised machine learning Self\u2010Organizing map algorithm, to identify the soft tissue induced RRR and quantitatively elucidate the governing relationship between the RRR and hydrostatic pressure in mucosa. The proposed governing equation has not only enabled a predictive simulation for RRR as showcased in this study, providing a biomechanical basis for optimizing prosthodontic treatments, but also extended the understanding of the mechanobiological responses in the soft\u2010hard tissue interfaces and the role in bone remodeling.<\/jats:p>","DOI":"10.1002\/adhm.202400091","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:44:41Z","timestamp":1715244281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Soft\u2010Tissue Driven Bone Remodeling Algorithm for Mandibular Residual Ridge Resorption Based on Patient CT Image Data"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6380-0641","authenticated-orcid":false,"given":"Jingxiao","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Aerospace Mechanical and Mechatronic Engineering the University of Sydney  Sydney 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwei","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Aerospace Mechanical and Mechatronic Engineering the University of Sydney  Sydney 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohana","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry and Integrative Pharmacogenomics Institute Universiti Teknologi MARA  Selangor 40450 Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junning","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Engineering, Mathematics and Physical Sciences University of Exeter Exeter EX4 4QJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Aerospace Mechanical and Mechatronic Engineering the University of Sydney  Sydney 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingrui","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Engineering, Mathematics and Physical Sciences University of Exeter Exeter EX4 4QJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keke","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute for Mechanical Process and Energy Engineering School of Engineering and Physical Sciences Heriot Watt University Edinburgh EH14 4AS UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Swain","sequence":"additional","affiliation":[{"name":"School of Aerospace Mechanical and Mechatronic Engineering the University of Sydney  Sydney 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-2145","authenticated-orcid":false,"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Aerospace Mechanical and Mechatronic Engineering the University of Sydney  Sydney 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"17","volume":"79","author":"Gunner E. 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