{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:15:55Z","timestamp":1791947755636,"version":"4.3.4"},"reference-count":238,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52202343"],"award-info":[{"award-number":["52202343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172204"],"award-info":[{"award-number":["82172204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute wounds are converted to chronic wounds due to advanced age and diabetic complications. Nanozymes catalyze ROS production to kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier to deliver drugs effectively. Nanozymes can be intergrateded into MNs delivery systems to improve painless drug delivery. It can also reduce the effective dose of drug sterilization while increasing delivery efficiency and effectively killing wounded bacteria while preventing drug resistance. This paper describes various types of metal nanozymes from previous studies and compares their mutual enhancement with nanozymes. The pooled results show that the MNs, through material innovation, are able to both penetrate the scab and deliver nanozymes and exert additional anti\u2010inflammatory and bactericidal effects. The catalytic effect of some of the nanozymes can also accelerate the lysis of the MNs or create a cascade reaction against inflammation and infection. However, the issue of increased toxicity associated with skin penetration and clinical translation remains a challenge. This study reviews the latest published results and corresponding challenges associated with the use of MNs combined with nanozymes for the treatment of wounds, providing further information for future research.<\/jats:p>","DOI":"10.1002\/adhm.202400101","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T03:59:42Z","timestamp":1716609582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Nanozyme\u2010Incorporated Microneedles for the Treatment of Chronic Wounds"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhiyuan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Burns The First Hospital Affiliated Anhui Medical University  Hefei Anhui 230032 P. R. China"},{"name":"School of Biomedical Engineering Research and Engineering Center of Biomedical Materials Anhui Medical University  Hefei Anhui 230032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Burns The First Hospital Affiliated Anhui Medical University  Hefei Anhui 230032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Burns The First Hospital Affiliated Anhui Medical University  Hefei Anhui 230032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon\u2010based Functional Materials and Devices Soochow University  Suzhou 215123 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Burns The First Hospital Affiliated Anhui Medical University  Hefei Anhui 230032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-440X","authenticated-orcid":false,"given":"Xianwen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Research and Engineering Center of Biomedical Materials Anhui Medical University  Hefei Anhui 230032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2015.1045879"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00155.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2017.09.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11030390"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b10153"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.08.004"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.11.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2315"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2020.1787980"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-7709-9_11"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00672"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00140"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805368"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00894"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201605296"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100336"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08702"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2020.17319"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.03.72"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002679"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120775"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.798563"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0031"},{"key":"e_1_2_10_20_1","first-page":"10","volume":"23","author":"Zhou B.","year":"2024","journal-title":"Small"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.10.174"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c04573"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202203064"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b02578"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c04527"},{"key":"e_1_2_10_23_1","author":"Frykberg R.","year":"2015","journal-title":"Adv Wound Care"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2017.09.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01295-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14052"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000222562.60260.f9"},{"key":"e_1_2_10_28_1","unstructured":"G.LuTheryn C.Hind P.Glynne\u2010Jones J. S.Webb J. M.Sutton D.Carugo presented at24th Eur. Symp. Ultrasound Contrast Imaging Rotterdam the Netherlands January\u00a02019."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0734"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.05.064"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700531"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.10.003"},{"key":"e_1_2_10_32_1","first-page":"111","volume":"23","author":"Zaidi A.","year":"2022","journal-title":"Intensive Care Med"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.09.002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00342.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0910538"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.06.001"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0307"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.01.001"},{"key":"e_1_2_10_41_1","first-page":"132","volume":"23","author":"Wager L.","year":"2015","journal-title":"Wound Practice Res."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240450403"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.09.007"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/2347-9264.165448"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0581"},{"key":"e_1_2_10_44_2","first-page":"141","volume":"21","author":"Serra M. B.","year":"2017","journal-title":"Int J Inflam"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1410-z"},{"key":"e_1_2_10_46_1","first-page":"445","volume":"32","author":"Harper D.","year":"2014","journal-title":"Surgery"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70566-1"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.07.008"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009283"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.11.552"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-018-0982-2"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4801.2006.00212.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.22028"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29710"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906670106"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0478-y"},{"key":"e_1_2_10_56_1","first-page":"14","volume":"55","author":"Basu S.","year":"2009","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.03.006"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1309\/LMBNSWKUI4JPN7SO"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.04.008"},{"key":"e_1_2_10_59_1","first-page":"S18","volume":"11","author":"GS S.","year":"2003","journal-title":"Wound Rep Reg"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2019.24.Sup9.S26"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24610"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2253"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup7.S24"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12426"},{"key":"e_1_2_10_65_1","first-page":"119","volume":"6","author":"Westby M. J.","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31822b675c"},{"key":"e_1_2_10_67_1","first-page":"243","volume":"31","author":"Kranke P.","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09492-1"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12205"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12165"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050700"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020950"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.02.023"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00345"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072357"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0178"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1819787"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn3758"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3543"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717541003667798"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.12.014"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00011"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00692.x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2021-0084"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.12.005"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20965-3"},{"key":"e_1_2_10_83_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.125488"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.08.015"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23710-y"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.02.016"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300261"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.007"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100308"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.023"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.08.054"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b01079"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2016.11.016"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03457"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/25\/13\/135101"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b04878"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC06671D"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC06671D"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.8b00153"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302640"},{"key":"e_1_2_10_100_1","first-page":"1139","volume":"36","author":"Peng Y.","year":"2020","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16544-7"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM00683E"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200121"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202005739"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1093073"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/am405009f"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12873"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000066"},{"key":"e_1_2_10_109_1","volume":"12","author":"Wang J.","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR02800B"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb2695"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23737-1"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200548"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113327"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.049"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201804466"},{"key":"e_1_2_10_117_1","first-page":"894","volume":"16","author":"Song J.","year":"2023","journal-title":"Bioinorg. Chem. Appl."},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01685-2"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202300592"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300568"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR02439F"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12429-6"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MD00397C"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12234115"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007356"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/js980042"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mee.2010.12.067"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.01.004"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2016.03.001"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.02.007"},{"key":"e_1_2_10_131_1","unstructured":"R. F.Donnelly T. R. R.Singh D. I.Morrow A. D.Woolfson 2012 434 30."},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013607400040"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10010024"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB01555J"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.05.026"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-018-0028-z"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1088\/0960-1317\/24\/1\/013001"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00542-006-0204-1"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-015-0001-4"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2020.03.028"},{"key":"e_1_2_10_140_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00098K"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00074"},{"key":"e_1_2_10_141_2","unstructured":"b)Z.Hughes R.Rahimi M.Ochoa B.Ziaie presented at2015 Transducers\u20102015 18th International Conference on Solid\u2010State Sensors Actuators and Microsystems (TRANSDUCERS)2015."},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425241003628171"},{"key":"e_1_2_10_142_2","doi-asserted-by":"publisher","DOI":"10.1038\/micronano.2017.34"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162518"},{"key":"e_1_2_10_143_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1343"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909197"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.03.031"},{"key":"e_1_2_10_146_1","unstructured":"J.\u2010W.Choi I.\u2010B.Park Y.\u2010M.Ha M.\u2010G.Jung S.\u2010h.Lee presented at2006 SICE\u2010ICASE International Joint Conference 2006."},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106392"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020542"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procir.2020.05.136"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.06.021"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111786"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202000086"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR07708B"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13060834"},{"key":"e_1_2_10_154_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002249"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NH00574C"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500357"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.02.004"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.061"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120020"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129335"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18809"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201905544"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126741"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804187"},{"key":"e_1_2_10_164_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b09563"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809544115"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw3329"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.01.059"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105566"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00626"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08140718"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00016-10"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR04171E"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475501"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08979"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.102168"},{"key":"e_1_2_10_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2014.12.081"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01371"},{"key":"e_1_2_10_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127240"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100056"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190211163948"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.041"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202210850"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.06.032"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100218"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300250"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-318131"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0080-9"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300576"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QM01512E"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.001"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06036"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300725"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902522"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202205292"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207961"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c02503"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.03.013"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c04539"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.12.006"},{"key":"e_1_2_10_199_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1032041"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-021-00512-4"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202203400"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113347"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.07.002"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01105"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.08.019"},{"key":"e_1_2_10_205_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00453"},{"key":"e_1_2_10_206_1","first-page":"2413","volume":"24","author":"Li J.","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119673"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.015"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202400101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:56:24Z","timestamp":1759794984000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202400101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,8]]},"references-count":238,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/adhm.202400101"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202400101","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,8]]},"assertion":[{"value":"2024-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400101"}}