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However, drug\u2010enabled thrombolysis treatment often encounters challenges such as short half\u2010life and low bioavailability. To address these issues, the design of erythrocyte\u2010membrane (EM) camouflaged nanocapsules (USIO\/UK@EM) incorporating ultra\u2010small iron oxide (USIO) and urokinase (UK) drug, which exhibits remarkable photothermal\/magnetothermal effects and drug delivery ability for venous\/arterial thrombolysis, is reported. USIO, UK, and EM are coextruded to fabricate USIO\/UK@EM with average sizes of 103.7\u00a0nm. As USIO\/UK@EM possesses wide photoabsorption and good magnetic properties, its solution demonstrates a temperature increase to 41.8\u201342.9\u00a0\u00b0C within 5\u00a0min when exposed to an 808\u00a0nm laser (0.33\u00a0mW cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) or alternating magnetic field (AMF). Such photothermal\/magnetothermal effect along with UK confers impressive thrombolytic rates of 82.4% and 74.2%, higher than that (\u224815%) achieved by UK alone. Further, the EM coating extends the circulating half\u2010life (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    = 3.28\u00a0h). When USIO\/UK@EM is administered to mice and rabbits, tail vein thrombus in mice and femoral artery thrombus in rabbits can be dissolved by the synergetic effect of thermothrombolysis and UK. Therefore, this study not only offers insights into the rational design of multifunctional biomimetic nanocapsules but also showcases a promising thrombolysis strategy utilizing nanomedicine.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202400127","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T11:28:43Z","timestamp":1714562923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Erythrocyte\u2010Membrane\u2010Camouflaged Magnetic Nanocapsules With Photothermal\/Magnetothermal Effects for Thrombolysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Liqiong","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishuai","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Interventional and Vascular Surgery Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Materials Science and Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Songjiang Maternity &amp; Child Health Hospital of Shanghai  Shanghai 201600 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 201600 P. 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