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Current strategies to mitigate the onset of a FBR include modification of the implant surface, release of anti\u2010inflammatory drugs, and cell\u2010scale implant porosity. The microporous annealed particle (MAP) scaffold platform is an injectable, porous biomaterial composed of individual microgels, which are annealed in situ to provide a structurally stable scaffold with cell\u2010scale microporosity. MAP scaffold does not induce a discernible foreign body response in vivo and, therefore, can be used a \u201cblank canvas\u201d for biomaterial\u2010mediated immunomodulation. Damage associated molecular patterns (DAMPs), such as IL\u201033, are potent regulators of type 2 immunity that play an important role in tissue repair. In this manuscript, IL\u201033 is conjugated to the microgel building\u2010blocks of MAP scaffold to generate a bioactive material (IL33\u2010MAP) capable of stimulating macrophages in vitro via a ST\u20102 receptor dependent pathway and modulating immune cell recruitment to the implant site in vivo, which indicates an upregulation of a type 2\u2010like immune response and downregulation of a type 1\u2010like immune response.<\/jats:p>","DOI":"10.1002\/adhm.202400249","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T13:23:38Z","timestamp":1713792218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Conjugation of IL\u201033 to Microporous Annealed Particle Scaffolds Enhances Type 2\u2010Like Immune Responses In Vitro and In Vivo"],"prefix":"10.1002","volume":"13","author":[{"given":"Colleen A.","family":"Roosa","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia  415 Lane Rd Charlottesville VA 22903 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"Lempke","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology Beirne B. 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