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The effectiveness of current clinical antibiotic therapy is hampered by the rise of drug\u2010resistant strains and the formation of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    biofilm. This paper reports a sonodynamic nanocomposite PtCu\n                    <jats:sub>3<\/jats:sub>\n                    \u2010PDA@AIPH@Fucoidan (PPAF), which consists of dopamine\u2010modified inorganic sonosensitizers PtCu\n                    <jats:sub>3<\/jats:sub>\n                    , alkyl radicals (R\u2022) generator AIPH and fucoidan, can penetrate the mucus layer, target\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , disrupt biofilms, and exhibit excellent bactericidal ability. In vitro experiments demonstrate that PPAF exhibits excellent acoustic kinetic properties, generating a significant amount of reactive oxygen species and oxygen\u2010independent R\u2022 for sterilization under ultrasound stimulation. Simultaneously, the produced N\n                    <jats:sub>2<\/jats:sub>\n                    can enhance the cavitation effect, aiding PPAF nanoparticles in penetrating the gastric mucus layer and disrupting biofilm integrity. This disruption allows more PPAF nanoparticles to bind to biofilm bacteria, facilitating the eradication of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . In vivo experiments demonstrate that ultrasound\u2010stimulated PPAF exhibited significant antibacterial efficacy against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . Moreover, it effectively modulated the expression levels of inflammatory factors and maintained gastrointestinal microbiota stability when compared to the antibiotic treatment group. In summary, PPAF nanoparticles present a potential alternative to antibiotics, offering an effective and healthy option for treating\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202400363","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T05:38:56Z","timestamp":1711949936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mucus and Biofilm Penetrating Nanoplatform as an Ultrasound\u2010Induced Free Radical Initiator for Targeted Treatment of\n                    <i>Helicobacter pylori<\/i>\n                    Infection"],"prefix":"10.1002","volume":"13","author":[{"given":"Jinjie","family":"Fan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Center for Drug Safety Evaluation and Research Zhengzhou 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