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Differentiation of transplanted stem cells has emerged as a therapeutic avenue to regenerate tissue architecture in damaged areas. Electrical stimulation is a promising approach for directing the differentiation outcomes and pattern of outgrowth of transplanted stem cells, however traditional inorganic bio\u2010electrodes can induce adverse effects such as inflammation. This study demonstrates the implementation of two organic thin films, a polymer\/reduced graphene oxide nanocomposite (P(rGO)) and PEDOT:PSS, that have favorable properties for implementation as conductive materials for electrical stimulation, as well as an inorganic indium tin oxide (ITO) conductive film. Transcriptomic analysis reveals that electrical stimulation improves neuronal differentiation of SH\u2010SY5Y cells on all three films, with the greatest effect for P(rGO). Unique material\u2010 and electrical stimuli\u2010mediated effects are observed, associated with differentiation, cell\u2010substrate adhesion, and translation. 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