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However, radiation\u2010induced skin damage during neoadjuvant radiotherapy exacerbates surgical injury, remarkably increasing the risk of refractory wounds and compromising the therapeutic effects. Radiation impedes wound healing by increasing the production of reactive oxygen species and inducing cell apoptosis and senescence. Here, a self\u2010assembling peptide (R\u2010peptide) and hyaluronic\u2010acid (HA)\u2010based and cordycepin\u2010loaded superstructure hydrogel is prepared for surgical incision healing after neoadjuvant radiotherapy. Results show that i) R\u2010peptide coassembles with HA to form biomimetic fiber bundle microstructure, in which R\u2010peptide drives the assembly of single fiber through \u03c0\u2013\u03c0 stacking and other forces and HA, as a single fiber adhesive, facilitates bunching through electrostatic interactions. ii) The biomimetic superstructure contributes to the adhesion and proliferation of cells in the surgical wound. iii) Aldehyde\u2010modified HA provides dynamic covalent binding sites for cordycepin to achieve responsive release, inhibiting radiation\u2010induced cellular senescence. iv) Arginine in the peptides provides antioxidant capacity and a substrate for the endogenous production of nitric oxide to promote wound healing and angiogenesis of surgical wounds after neoadjuvant radiotherapy.<\/jats:p>","DOI":"10.1002\/adhm.202400406","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:23:51Z","timestamp":1714382631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Glucopeptide Superstructure Hydrogel Promotes Surgical Wound Healing Following Neoadjuvant Radiotherapy by Producing NO and Anticellular Senescence"],"prefix":"10.1002","volume":"13","author":[{"given":"Hang","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Tianjin Institutes of Health Science Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300192 P. 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