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Manganese cations (Mn<jats:sup>2+<\/jats:sup>) directly activate the cGAS\/STING pathway and induce the unique catalytic synthesis of 2\u20323'\u2010cGAMP to facilitate type I IFN production, thereby enhancing innate immunity. Here, a telodendrimer and Mn<jats:sup>2+<\/jats:sup>\u2010based nanodriver (PLHM) with a small size is developed, which effectively target lymph nodes through the blood circulation and exhibit tumor\u2010preventive effects at low doses of Mn<jats:sup>2+<\/jats:sup> (3.7\u00a0mg kg<jats:sup>\u22121<\/jats:sup>). On the other hand, the PLHM nanodriver also exhibits apparent antitumor effects in GBM\u2010bearing mice via inducing in vivo innate immune responses. The combination of PLHM with doxorubicin nanoparticles (PLHM\u2010DOX NPs) results in superior inhibition of tumor growth in GBM\u2010bearing mice due to the synergistic potentiation of STING pathway functionality by Mn<jats:sup>2+<\/jats:sup> and the presence of cytoplasmic DNA. These findings demonstrate that PLHM\u2010DOX NPs effectively stimulate innate immunity, promote dendritic cell maturation, and orchestrate cascaded infiltration of CD8 cytotoxic T lymphocytes within glioblastomas characterized by low immunogenicity. These nanodivers chelated with Mn<jats:sup>2+<\/jats:sup> show promising potential for tumor prevention and antitumor effects on glioblastoma by activating the STING pathway.<\/jats:p>","DOI":"10.1002\/adhm.202400421","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:09:32Z","timestamp":1712275772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Manganese\u2010Based Nanodriver Coordinates Tumor Prevention and Suppression through STING Activation in Glioblastoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Shenzhen Clinical Medical College Guangzhou University of Chinese Medicine  Shenzhen 518000 China"},{"name":"Department of Neurosurgery Longgang Central Hospital of Shenzhen  Shenzhen 518116 China"},{"name":"Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical 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