{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:49:58Z","timestamp":1792518598090,"version":"4.5.0"},"reference-count":104,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NNCI\u20102025233"],"award-info":[{"award-number":["NNCI\u20102025233"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","award":["2237827"],"award-info":[{"award-number":["2237827"]}],"id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R21DC019184"],"award-info":[{"award-number":["R21DC019184"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable noninvasive drug delivery across skin\u2010like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with the lipid bilayers in the stratum corneum to create defects as diffusion paths, their interactions with the delivery system, such as polymers forming a hydrogel, can compromise gelation, formulation stability, and drug diffusion. To overcome this\u00a0challenge, differing interactions between CPEs and the hydrogel system are explored, especially those with sodium dodecyl sulfate (SDS), an ionic surfactant and a common CPE, and those with methyl laurate (ML), a nonionic counterpart with a similar length alkyl chain. Notably, the use of ML effectively decouples permeation enhancement from gelation, enabling sustained delivery across TMs to treat acute otitis media (AOM),\u00a0which is not possible with the use of SDS. Ciprofloxacin and ML are shown to form a pseudo\u2010surfactant that significantly boosts transtympanic permeation. The middle ear ciprofloxacin concentration is increased by 70\u2010fold in vivo in a chinchilla AOM model, yielding superior efficacy and biocompatibility than the previous highest\u2010performing formulation. Beyond improved efficacy and biocompatibility, this single\u2010CPE formulation significantly accelerates its progression toward clinical deployment.<\/jats:p>","DOI":"10.1002\/adhm.202400457","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:29:05Z","timestamp":1715581745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Pseudo\u2010Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-1339","authenticated-orcid":false,"given":"Sophie S.","family":"Liu","sequence":"first","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"},{"name":"Meinig School of Biomedical Engineering Cornell University  Weill Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-4332","authenticated-orcid":false,"given":"Joanna M.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science University of Minnesota  421 Washington Ave. Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-4440","authenticated-orcid":false,"given":"Zhongmou","family":"Chao","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-3273","authenticated-orcid":false,"given":"Ruye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology Cornell University  Baker Laboratory Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-7397","authenticated-orcid":false,"given":"Shuxian","family":"Wen","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-279X","authenticated-orcid":false,"given":"Ally","family":"Garza","sequence":"additional","affiliation":[{"name":"Department of Health and Biomedical Sciences University of Texas Rio Grande Valley 1201 W University Drive  Edinburg TX 78539 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Tang","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7773-0835","authenticated-orcid":false,"given":"Susan","family":"Daniel","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-1278","authenticated-orcid":false,"given":"Frank S.","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science University of Minnesota  421 Washington Ave. Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-7422","authenticated-orcid":false,"given":"Jingjie","family":"Yeo","sequence":"additional","affiliation":[{"name":"Sibley School of Mechanical and Aerospace Engineering Cornell University  Upson Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-6999","authenticated-orcid":false,"given":"Michelle A.","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science University of Minnesota  421 Washington Ave. Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6427-026X","authenticated-orcid":false,"given":"Rong","family":"Yang","sequence":"additional","affiliation":[{"name":"Robert F. Smith School of Chemical and Biomolecular Engineering Cornell University  Olin Hall Ithaca NY 14850 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501176102"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.04.030"},{"key":"e_1_2_9_1_3","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903338758"},{"key":"e_1_2_9_1_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113925"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.025"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9542-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp300441c"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2018.021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0927-7757(01)00538-6"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/la00002a029"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1021\/j100013a068"},{"key":"e_1_2_9_4_4","doi-asserted-by":"publisher","DOI":"10.1080\/01932690701751876"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09384-6"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.08.059"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjche.2019.03.019"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2018.01.089"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1080\/01932690902735058"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf4363"},{"key":"e_1_2_9_8_1","first-page":"151","volume":"111","author":"Thomas J. P.","year":"2014","journal-title":"Dtsch. Arztebl. Int."},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000810"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.08.043"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7283-1-24"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.09.030"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.1038\/5507"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.06.005"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.12.023"},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000187044.73791.92"},{"key":"e_1_2_9_11_4","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2018.1464022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560802489262"},{"key":"e_1_2_9_12_2","unstructured":"b)FDA Ciprodex: Highlights of prescribing information https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/021537s017lbl.pdf(accessed: December 2023)."},{"key":"e_1_2_9_13_1","unstructured":"FDA Cetraxal: Highlights of prescribing information https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/021918lbl.pdf(accessed: December 2023)."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.10.025"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.06.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.07.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2021.128246"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.03.019"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.1021\/ma00068a010"},{"key":"e_1_2_9_16_4","doi-asserted-by":"publisher","DOI":"10.1021\/ma00093a016"},{"key":"e_1_2_9_16_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.10.030"},{"key":"e_1_2_9_16_6","doi-asserted-by":"publisher","DOI":"10.1021\/la304836e"},{"key":"e_1_2_9_16_7","doi-asserted-by":"publisher","DOI":"10.1021\/la00020a019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcis.1997.4880"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0927-7757(94)03028-X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-3057(98)00129-3"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/la062622p"},{"key":"e_1_2_9_18_3","doi-asserted-by":"publisher","DOI":"10.1021\/la00023a017"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2015.08.016"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1063\/5.0057090"},{"key":"e_1_2_9_19_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.3c00088"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2004.06.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(85)90197-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/la000899y"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/la001075j"},{"key":"e_1_2_9_22_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.10.176"},{"key":"e_1_2_9_22_4","first-page":"12","author":"Kancharla S.","year":"2020","journal-title":"Polymers (Basel)"},{"key":"e_1_2_9_22_5","doi-asserted-by":"publisher","DOI":"10.1021\/la00013a013"},{"key":"e_1_2_9_23_1","unstructured":"Chemical Book Methyl laurate: CAS DataBase List https:\/\/www.chemicalbook.com\/ChemicalProductProperty_EN_CB6274029.htm(accessed: December 2023)."},{"key":"e_1_2_9_24_1","unstructured":"a)PubChem Ciprofloxacin (Compound) https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Ciprofloxacin(accessed: December 2023);"},{"key":"e_1_2_9_24_2","first-page":"307","volume":"42","author":"Edmunds A. L.","year":"2017","journal-title":"P T"},{"key":"e_1_2_9_25_1","unstructured":"PubChem Ammonium Chloride https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Ammonium\u2010Chloride(accessed: December 2023)."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123415"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201602123"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6017(200105)90:5<545::AID-JPS1012>3.0.CO;2-H"},{"key":"e_1_2_9_29_1","volume-title":"Molecular Biology of the Cell","author":"Alberts B.","year":"2002"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ct3003157"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00878"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114045"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06813"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2012.02.008"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(83)90145-X"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb00716.x"},{"key":"e_1_2_9_34_1","unstructured":"FDA Otiprio: Highlights of prescribing information https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/207986s002lbl.pdf(accessed: November 2023)."},{"key":"e_1_2_9_35_1","unstructured":"a)DailyMed Drug label information: Fentanyl system \u2013 fentanyl patch https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=242759ef\u2010cb6d\u20104e3e\u20109f8d\u20105e31efa1f289(accessed: November 2023);"},{"key":"e_1_2_9_35_2","unstructured":"b)DailyMed Drug label information: Androderm \u2013 testosterone patch https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=e58a5328\u2010fdd9\u201040cb\u2010a19f\u20108ed798989b9c(accessed: November 2023)."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3539-3541.2003"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00192-09"},{"key":"e_1_2_9_37_1","first-page":"185","volume":"47","author":"Ananthapadmanabhan K. P.","year":"1996","journal-title":"J. Soc. Cosmet. Chem."},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2019.06.030"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0001"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816645526"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.63"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2022.05.002"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000200"},{"key":"e_1_2_9_40_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.040"},{"key":"e_1_2_9_40_4","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.811652"},{"key":"e_1_2_9_41_1","first-page":"128","volume":"32","author":"Kumar L.","year":"2008","journal-title":"Pharm. Technol."},{"key":"e_1_2_9_42_1","first-page":"9","volume":"32","author":"Heiney P. A.","year":"2005","journal-title":"Int. Union Crystallogr."},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0014475"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp973084f"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23354"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00935"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00169"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01176"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1493"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CP06869D"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1606"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct300715s"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.0c00063"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1088\/2058-8585\/ac808a"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/adhm.202400457","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202400457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:02:00Z","timestamp":1759777320000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202400457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":104,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/adhm.202400457"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202400457","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]},"assertion":[{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400457"}}