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Nitric oxide (NO) is an integral part of endothelial homeostasis, maintaining platelet quiescence and facilitating oxidative\/nitrosative stress against pathogens. Recently, it is shown that the surface evolution of NO can mediate cell\u2010surface interactions. However, this technique alone cannot prevent the biofouling inherent in device failure with dynamic blood\u2010contacting applications. This work proposes an endothelium\u2010mimicking surface design pairing controlled NO release with an inherently antifouling polyethylene glycol interface (NO+PEG). This simple, robust, and scalable platform develops surface\u2010localized NO availability with surface hydration, leading to a significant reduction in protein adsorption as well as bacteria\/platelet adhesion. Further in vivo thrombogenicity studies show a decrease in thrombus formation on NO+PEG interfaces, with preservation of circulating platelet and white blood cell counts, maintenance of activated clotting time, and reduced coagulation cascade activation. It is anticipated that this bio\u2010inspired surface design will enable a facile alternative to existing surface technologies to address clinical manifestations of infection and thrombosis in dynamic blood\u2010contacting environments.<\/jats:p>","DOI":"10.1002\/adhm.202400492","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T09:24:04Z","timestamp":1719307444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Surface Engineering for Endothelium\u2010Mimicking Functions to Combat Infection and Thrombosis in Extracorporeal Life Support Technologies"],"prefix":"10.1002","volume":"13","author":[{"given":"Morgan","family":"Ashcraft","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences College of Pharmacy University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Garren","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Lautner\u2010Csorba","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Pinon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences College of Pharmacy University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagney","family":"Crowley","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeniselis","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical Center  Ann Arbor Michigan 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Brisbois","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-7374","authenticated-orcid":false,"given":"Hitesh","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences College of Pharmacy University of Georgia  Athens Georgia 30602 USA"},{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002700"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87026-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198392"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.02.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13520"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89108-4"},{"key":"e_1_2_8_7_1","first-page":"1171","volume":"36","author":"Wang J. 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