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The jaw vascular unit (JVU), encompassing both vascular and lymphatic vessels, plays a crucial role in maintaining tissue fluid homeostasis and contributes to the pathological process in inflammatory diseases of the jaw. This study presents a novel approach for treating periodontitis through the development of an injectable thermosensitive gel (CH\u2010BPNs\u2010NBP). The gel formulation incorporates black phosphorus nanosheets (BPNs), which are notable for their ROS\u2010scavenging properties, and dl\u20103\u2010n\u2010butylphthalide (NBP), a vasodilator that promotes lymphatic vessel function within the JVU. These results demonstrate that the designed thermosensitive gel serve as a controlled release system, delivering BPNs and NBP to the site of inflammation. CH\u2010BPNs\u2010NBP not only protects macrophages and human lymphatic endothelial cells from ROS attack but also promotes M2 polarization and lymphatic function. In in vivo studies, this work observes a significant reduction in inflammation and tissue damage, accompanied by a notable promotion of alveolar bone regeneration. This research introduces a promising therapeutic strategy for periodontitis, leveraging the unique properties of BPNs and NBP within an injectable thermosensitive gel.<\/jats:p>","DOI":"10.1002\/adhm.202400533","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T07:48:38Z","timestamp":1715240918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Injectable Thermosensitive Gel CH\u2010BPNs\u2010NBP for Effective Periodontitis Treatment through ROS\u2010Scavenging and Jaw Vascular Unit Protection"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University Jiangsu Province Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical 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