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Currently, these Cages suffer from issues related to mismatched elastic modulus and insufficient bone integration capability. Therefore, a gel\u2010casting technique is utilized to fabricate a biomimetic porous titanium alloy material from Ti6Al4V powder. The biomimetic porous Ti6Al4V is compared with polyetheretherketone (PEEK) and 3D\u2010printed Ti6Al4V materials and their respective Cages. Systematic validation is performed through mechanical testing, in vitro cell, in vivo rabbit bone defect implantation, and ovine anterior cervical discectomy and fusion experiments to evaluate the mechanical and biological performance of the materials. Although all three materials demonstrate good biocompatibility and osseointegration properties, the biomimetic porous Ti6Al4V, with its excellent mechanical properties and a structure closely resembling bone trabecular tissue, exhibited superior bone ingrowth and osseointegration performance. Compared to the PEEK and 3D\u2010printed Ti6Al4V Cages, the biomimetic porous Ti6Al4V Cage outperforms in terms of intervertebral fusion performance, achieving excellent intervertebral fusion without the need for bone grafting, thereby enhancing cervical vertebra stability. This biomimetic porous Ti6Al4V Cage offers cost\u2010effectiveness, presenting significant potential for clinical applications in spinal surgery.<\/jats:p>","DOI":"10.1002\/adhm.202400550","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T06:06:25Z","timestamp":1721369185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biomimetic Porous Ti6Al4V Implants: A Novel Interbody Fusion Cage via Gel\u2010Casting Technique to Promote Spine Fusion"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-6425","authenticated-orcid":false,"given":"Xinyu","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Orthopedics Peking University Third Hospital Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University Third Hospital Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University Third Hospital Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University Third Hospital Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 250000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shen","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center Peking University Third Hospital  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Pain Medical Center Peking University Third Hospital  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[{"name":"Pain Medical Center Peking University Third Hospital  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Jin","sequence":"additional","affiliation":[{"name":"ZhongAoHuiCheng Technology Co. 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