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This study introduces a novel approach involving the encapsulation of collagen monomers within zwitterionic nanoliposomes, termed Lip\u2010Cols, and the controlled formation of collagen fibrils through electric fields (EF) stimulation. The results reveal the self\u2010assembly process of Lip\u2010Cols through electroporation and a pH gradient change uniquely triggered by EF, leading to the alignment and aggregation of Lip\u2010Cols on the electrode interface. Notably, Lip\u2010Cols exhibit the capability to direct the orientation of collagen fibrils within human dermal fibroblasts. In conjunction with EF, Lip\u2010Cols can deliver collagen into the dermal layer and increase the collagen amount in the skin. The findings provide novel insights into the directed formation of collagen fibrils via electrical stimulation and the potential of Lip\u2010Cols as a non\u2010invasive drug delivery system for anti\u2010aging applications.<\/jats:p>","DOI":"10.1002\/adhm.202400693","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T06:41:44Z","timestamp":1716619304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Topical Nanoliposomal Collagen Delivery for Targeted Fibril Formation by Electrical Stimulation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-5140","authenticated-orcid":false,"given":"Albertus Ivan","family":"Brilian","sequence":"first","affiliation":[{"name":"Department of Chemistry and Institute of Biological Interfaces Sogang University  35 Baekbeom\u2010ro, Mapo\u2010gu Seoul 04107 Republic of 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