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Metastatic cancer cells are highly invasive in part due to the presence of the glycan matrix in the cell membrane. Using a rational designed bio\u2010orthogonal reaction, the cancer cell surface is reconstructed in situ by incorporating endogenous polysialic acids in the glycan matrix on the cell membrane to form a mesh\u2010like network, called cancer mask. The network of the glycan matrix can not only immobilize cancer cells but also effectively block the stimulation of metastasis promoters to tumor cells and inhibit the formation of epithelial to mesenchymal transition (EMT), causing metastatic cancer cells incarceration. The results demonstrate a new strategy to control and even eliminate the cancer metastasis that is a major cause of treatment failure and poor patient outcome.<\/jats:p>","DOI":"10.1002\/adhm.202400742","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T09:54:47Z","timestamp":1714211687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Engineering Cancer Mask to Immobilize Tumor Cells and Block Metastasis"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaoke","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Nanjing University  Nanjing 210093 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Nanjing University  Nanjing 210093 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