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Organic probes exhibit high potential in clinical translation, due to advantages such as precise structure design, low toxicity, and post\u2010modifications convenience. In related preparation, enhancement of NIR\u2010II tail emission from NIR\u2010I dyes is an efficient method. In particular, the promotion of twisted intramolecular charge transfer (TICT) of relevant NIR\u2010I dyes is a convenient protocol. However, present TICT\u2010type probes still show disadvantages in relatively low emission, large particle sizes, or limited choice of NIR\u2010I dyes, etc. Herein, the synthesis of stable small\u2010sized polymer NIR\u2010II fluoroprobes (e.g., 7.2\u00a0nm), integrating TICT and F\u00f6rster resonance energy transfer process to synergistically enhance the NIR\u2010II emission is reported. Strong enhanced emissions can be obtained from various NIR\u2010I dyes and lanthanide elements (e.g., twelvefold at 1250\u00a0nm from Nd\u2010DTPA\/IR\u2010808 sample). The fluorophore provides high\u2010resolution angiography, with high\u2010contrast imaging on middle cerebral artery occlusion model mice for distinguishing occlusion. The fluorophore can be rapidly excreted from the kidney (urine \u224865% within 4\u00a0h) in normal mice and exhibits long\u2010term renal retention on acute kidney injury mice, showing potential applications in the prognosis of kidney diseases. This development provides an effective strategy to design and synthesize effective NIR\u2010II fluoroprobes.<\/jats:p>","DOI":"10.1002\/adhm.202400760","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T06:10:42Z","timestamp":1714803042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preparation of NIR\u2010II Polymer Nanoprobe Through Twisted Intramolecular Charge Transfer and F\u00f6rster Resonance Energy Transfer of NIR\u2010I Dye"],"prefix":"10.1002","volume":"13","author":[{"given":"Bin","family":"Xia","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Value\u2010Added Catalytic Conversion and Reaction Engineering Anhui Province Engineering Research Center of Flexible and Intelligent Materials Hefei University of Technology  Hefei 230009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ren","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Nano\u2010Bio Interface Division of Nanobiomedicine and i\u2010Lab Suzhou Institute of Nano\u2010Tech and Nano\u2010Bionics Chinese Academy of Sciences  Suzhou 215123 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei 230001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Chuan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Value\u2010Added Catalytic Conversion and Reaction Engineering Anhui Province Engineering Research Center of Flexible and Intelligent Materials Hefei University of Technology  Hefei 230009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Lin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Suzhou Medical College Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou 215123 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Value\u2010Added Catalytic Conversion and Reaction Engineering Anhui Province Engineering Research Center of Flexible and Intelligent Materials Hefei University of Technology  Hefei 230009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of USTC Division of Life Science and Medicine University of Science and Technology of China  Hefei 230001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Long","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Anhui No. 2 Provincial People's Hospital  Hefei 230041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Duo","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Physics Hefei University of Technology  Hefei 230009 P.R. 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