{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:56:50Z","timestamp":1785621410986,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21788102"],"award-info":[{"award-number":["21788102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271093"],"award-info":[{"award-number":["22271093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21971064"],"award-info":[{"award-number":["21971064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["222201717003"],"award-info":[{"award-number":["222201717003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["50321101918001"],"award-info":[{"award-number":["50321101918001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mild photothermal therapy (PTT) has attracted attention for effectively avoiding the severe side effects associated with high\u2010temperature tumor ablation. However, its progress is hindered by the limited availability of high\u2010performance photothermal agents (PTAs) and the thermoresistance of cancer cells induced by heat shock reactions. Herein, this work proposes a new strategy to expand the library of high\u2010performance organic small\u2010molecule PTAs and utilize it to construct a multifunctional nano\u2010theranostic platform. By incorporating additional acceptors and appropriate \u03c0\u2010bridges, a diketopyrrolopyrrole\u2010based dye BDB is developed, which exhibits strong absorption and bright fluorescence emission in the near\u2010infrared (NIR)\u00a0region. Subsequently, BDB is co\u2010coated with the heat shock protein (HSP) inhibitor tanespimycin (17\u2010AAG) using the functional amphiphilic polymers DSPE\u2010Hyd\u2010PEG\n                    <jats:sub>2000<\/jats:sub>\n                    \u2010cRGD to form an all\u2010in\u2010one nanoplatform BAG NPs. As a result, BAG NPs can precisely target tumor tissue, guide the treatment process in real\u2010time through NIR\u2010II fluorescence\/photoacoustic\/photothermal imaging, and release 17\u2010AAG on demand to enhance mild PTT. Additionally, the mild PTT\u00a0has been demonstrated to induce immunogenic cell death (ICD) and activate a systemic anti\u2010tumor immune response, thereby suppressing both primary and distant tumors. Overall, this study presents a multifunctional nanoplatform designed for precise mild PTT combined with immunotherapy for effective tumor treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202400766","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T05:55:44Z","timestamp":1721022944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Diketopyrrolopyrrole\u2010Based All\u2010in\u2010One Nanoplatform for Self\u2010Reinforcing Mild Photothermal Therapy Cascade Immunotherapy for Tumors"],"prefix":"10.1002","volume":"13","author":[{"given":"Xinsheng","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Materials College of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaini","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010pancreatic Surgery Renji Hospital Shanghai Jiaotong University School of Medicine  Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Materials College of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Materials College of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyang","family":"Sha","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Materials College of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010pancreatic Surgery Renji Hospital Shanghai Jiaotong University School of Medicine  Shanghai 200127 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yi","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-0007","authenticated-orcid":false,"given":"Jianli","family":"Hua","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Materials College of Chemistry and Molecular Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00074H"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.10.001"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.08.023"},{"key":"e_1_2_11_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302634"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c07592"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553009114550441"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.11.001"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100738"},{"key":"e_1_2_11_4_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.11.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909391"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300929"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901954"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC06143K"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214330"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202015422"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00940"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01913"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR02291H"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119976"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00309"},{"key":"e_1_2_11_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801122"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03005"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300232"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122455"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c01128"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302639"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202209258"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307797"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102213"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.25"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07193"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202102312"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b06483"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10019"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35346F"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201001801"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106797"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC05041F"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001042"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008356"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207213"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202206346"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.11.039"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202106091"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b02331"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04222-8"},{"key":"e_1_2_11_29_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b03936"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03009-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13222"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101266"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202360"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304032"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202400766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202400766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202400766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:39:14Z","timestamp":1773326354000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202400766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":53,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/adhm.202400766"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202400766","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"assertion":[{"value":"2024-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400766"}}