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Such advancements render these dyes applicable across a wide spectrum of uses, ranging from second\u2010window near\u2010infrared (NIR\u2010II) bioimaging to organic photovoltaics. Nevertheless, the inherent benefits of long conjugation are often accompanied by persistent challenges like aggregation, fluorescence quenching, absorption blueshift, and low stability and poor water solubility. Herein, a unique structural design strategy termed \u201chomo\u2010dyad with outer hydration layer\u201d is introduced to address these inherent problems, tailored for the development of imaging probes exhibiting long absorption\/emission wavelengths. This approach involves bringing two heptamethine cyanines together through a flexible linker, forming a homo\u2010dyad structure, while strategically attaching four polyethylene glycol (PEG9) chains to the terminal heterocycles. This approach imparts excellent water solubility, biocompatibility, and enhanced chemical, photo\u2010, and spectral stability for the dyes. Utilizing this strategy, a biomarker\u2010activatable probe (HD\u2010FL\u20104PEG9\u2010N) for NIR\u2010II fluorescent and 3D multispectral optoacoustic tomography imaging is developed, and its effectiveness in disease visualization. It can not only serve as an injectable probe for acute kidney injury imaging due to its high water solubility, but also a sprayable probe for imaging bacterial\u2010infected wounds.<\/jats:p>","DOI":"10.1002\/adhm.202400791","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:25:32Z","timestamp":1712575532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Homo\u2010Dyad with Outer Hydration Layer Approach for Developing NIR\u2010II Chromophore of High Stability and Water\u2010Solubility as Injectable and Sprayable Optical Probe"],"prefix":"10.1002","volume":"13","author":[{"given":"Zunpan","family":"She","sequence":"first","affiliation":[{"name":"Biomedical Division State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates College of Materials Science and Engineering South China University of 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