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Among them,\n                    <jats:italic>T. mentagrophytes<\/jats:italic>\n                    and\n                    <jats:italic>M. canis<\/jats:italic>\n                    are the dominating pathogens that cause dermatophytosis in humans. Though anti\u2010fungal treatments are available, the widespread drug resistance and minimal efficacy of conventional therapies cause recurring infections. In addition, prolonged anti\u2010fungal medications induce several systemic side effects, including hepatotoxicity and leucopenia. The anti\u2010dermatophytic formulation of biocompatible essential oil components (EOCs) is attractive due to their highly potent anti\u2010dermatophytic action. Herein, two EOCs, Eugenol (EU) and Isoeugenol (IU), incorporated emulsion hydrogel (EOCs\u2010EHG) synthesized from hydroxypropylmethyl cellulose and poly(ethylene glycol) methyl ether methacrylate. The cytocompatibility of the hydrogels is confirmed by treating them with fibroblast and keratinocyte cell lines. The EOCs\u2010EHG demonstrated pH and temperature\u2010responsive sustained release of entrapped EOCs and inhibited fungal spore germination.\n                    <jats:italic>T. mentagrophytes<\/jats:italic>\n                    and\n                    <jats:italic>M. canis<\/jats:italic>\n                    biofilms are eradicated at a minimal inhibitory concentration of 2\u00a0\u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    each of EU and IU. The in vivo anti\u2010dermatophytic activity of EOCs\u2010EHG is confirmed in dermatophyte\u2010infected Wistar albino rat models. The topical application of EOCs\u2010EHG demonstrated complete infection eradication and facilitated skin regeneration, emphasizing the therapeutic potential of EOCs\u2010EHG against dermatophytosis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202400811","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T02:50:56Z","timestamp":1723603856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Essential Oil Components Incorporated Emulsion Hydrogels for Eradicating Dermatophytosis Caused by Pathogenic Fungi\n                    <i>Trichophyton mentagrophytes<\/i>\n                    and\n                    <i>Microsporum canis<\/i>"],"prefix":"10.1002","volume":"13","author":[{"given":"Namitha K.","family":"Preman","sequence":"first","affiliation":[{"name":"Polymer Nanobiomaterials Research Laboratory Smart Materials and Devices (SMAD) Division Yenepoya Research Centre Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhitha","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Yenepoya Medical College Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandesh G.","family":"Sanjeeva","sequence":"additional","affiliation":[{"name":"Polymer Nanobiomaterials Research Laboratory Smart Materials and Devices (SMAD) Division Yenepoya Research Centre Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suprith","family":"Surya","sequence":"additional","affiliation":[{"name":"Advanced Surgical Skill ENhancement Division (ASSEND) Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukesh","family":"Kumar B","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Biotechnology Yenepoya Research Centre Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath M.","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Yenepoya Medical College Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh P.","family":"Shastry","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Biotechnology Yenepoya Research Centre Yenepoya (Deemed to be University)  Mangalore 575018 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-2515","authenticated-orcid":false,"given":"Renjith P.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Polymer Nanobiomaterials Research Laboratory 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