{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:21:25Z","timestamp":1791861685903,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Remote health monitoring and treatment serve as critical drivers for advancing health equity, bridging geographical and socioeconomic disparities, ensuring equitable access to quality healthcare for those in underserved or remote regions. By democratizing healthcare, this approach offers timely interventions, continuous monitoring, and personalized care independent of one's location or socioeconomic status, thereby striving for an equitable distribution of health resources and outcomes. Meanwhile, microneedle arrays (MNAs), revolutionize painless and minimally invasive access to interstitial fluid for drug delivery and diagnostics. This paper introduces an integrated theranostic MNA system employing an array of colorimetric sensors to quantitatively measure \u2010pH, glucose, and lactate, alongside a remotely\u2010triggered system enabling on\u2010demand drug delivery. Integration of an ultrasonic atomizer streamlines the drug delivery, facilitating rapid, pumpless, and point\u2010of\u2010care drug delivery, enhancing system portability while reducing complexities. An accompanying smartphone application interfaces the sensing and drug delivery components. Demonstrated capabilities include detecting pH (3 to 8), glucose (up to 16\u00a0m<jats:sc>m<\/jats:sc>), and lactate (up to 1.6\u00a0m<jats:sc>m<\/jats:sc>), showcasing on\u2010demand drug delivery, and assessing delivery system performance via a scratch assay. This innovative approach confronts drug delivery challenges, particularly in managing chronic diseases requiring long\u2010term treatment, while also offering avenues for non\u2010invasive health monitoring through microneedle\u2010based sensors.<\/jats:p>","DOI":"10.1002\/adhm.202400881","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T11:49:41Z","timestamp":1716464981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Remote\u2010Controlled Sensing and Drug Delivery via 3D\u2010Printed Hollow Microneedles"],"prefix":"10.1002","volume":"13","author":[{"given":"Mahmood","family":"Razzaghi","sequence":"first","affiliation":[{"name":"Mechanical Engineering Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria  Victoria BC V8P 5C2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Alexander","family":"Ninan","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria  Victoria BC V8P 5C2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Azimzadeh","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria  Victoria BC V8P 5C2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esfandyar","family":"Askari","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria  Victoria BC V8P 5C2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Hassani","family":"Najafabadi","sequence":"additional","affiliation":[{"name":"Drug Delivery and Immunoengineering Terasaki Institute for Biomedical Innovations  Los Angeles CA 90050 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khademhosseini","sequence":"additional","affiliation":[{"name":"Drug Delivery and Immunoengineering Terasaki Institute for Biomedical Innovations  Los Angeles CA 90050 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-6557","authenticated-orcid":false,"given":"Mohsen","family":"Akbari","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria  Victoria BC V8P 5C2 Canada"},{"name":"Drug Delivery and Immunoengineering Terasaki Institute for Biomedical Innovations  Los Angeles CA 90050 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01614-0"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-020-00378-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2021.3079217"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601355"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16521"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41928-019-0286-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122075"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16268-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100194"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2020.02.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2012.2189020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.38"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0070"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114955"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114412"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00887-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2018.1539497"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13152405"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201702243"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162815"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi14061157"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.04.063"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2020.101815"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5127778"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.045"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15061389"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000307"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12723"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.03.007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi12111321"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.04.005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.078"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3LC00160A"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122546"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.102012"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2019.04.008"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-019-0077-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118992"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2017.03.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/micronano.2017.34"},{"key":"e_1_2_9_41_1","first-page":"240","volume":"9","author":"Chen H.","year":"2019","journal-title":"Drug DeliveryTransl. Res."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/micronano.2017.73"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172043"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0169-8"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi12010023"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.10.030"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-018-0028-z"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.9734\/JPRI\/2017\/36164"},{"key":"e_1_2_9_49_1","first-page":"575","volume":"49","author":"Park B. J.","year":"2018","journal-title":"J. Pharm. Invest."},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.01.031"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-021-02153-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2019.0278"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-100717-4.00001-6"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2018.06.016"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41205-019-0039-x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00098K"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi13081319"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi13071099"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101036"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121435"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113997"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2012.05.055"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00655"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200201"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203233"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00404-18"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0912-6"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.015"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909197"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi11010017"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1109\/JMEMS.2020.3003628"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.10.021"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.481"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202400881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:13:18Z","timestamp":1759785198000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202400881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":73,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/adhm.202400881"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202400881","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2024-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400881"}}