{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:34:40Z","timestamp":1791884080179,"version":"4.3.4"},"reference-count":66,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1A2C2011485"],"award-info":[{"award-number":["NRF\u20102021R1A2C2011485"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1A5A6000760"],"award-info":[{"award-number":["NRF\u20102022R1A5A6000760"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u2010RS\u20102023\u201000230826"],"award-info":[{"award-number":["NRF\u2010RS\u20102023\u201000230826"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1A2C2094730"],"award-info":[{"award-number":["NRF\u20102021R1A2C2094730"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The successful implementation of photothermal therapy (PTT) in cancer treatment hinges on the development of highly effective photothermal agents (PTAs). Boron dipyrromethene (BODIPY) dyes, being well known for their high brightness and quantum efficiencies, are the antithesis of PTAs. Nonetheless, a systematic exploration of the photophysics and photothermal characteristics of a series of \u03c0\u2010extended BODIPY dyes with high absorptivity in the near\u2010infrared (NIR) region has achieved superior photothermal conversion efficiencies (&gt;90%), in both monomeric state and nanoparticles after encapsulation in a biocompatible polyethyleneglycol 1,2\u2010distearoyl\u2010\n                    <jats:italic>sn<\/jats:italic>\n                    \u2010glycero\u20103\u2010phosphoethanolamine\u2010N\u2010[methoxy\u2010(polyethylene glycol)\u20102000]. Optimal PTA candidates combine strong NIR absorption provided by extended donor\u2013acceptor conjugation and an optimization of the electronic and steric effects of\n                    <jats:italic>meso<\/jats:italic>\n                    \u2010substituents to maximize photothermal conversion performance. The PTT\u2010optimized\n                    <jats:italic>meso<\/jats:italic>\n                    \u2010CF\n                    <jats:sub>3<\/jats:sub>\n                    \u2010BODIPY,\n                    <jats:bold>T<\/jats:bold>\n                    CF\n                    <jats:sub>3<\/jats:sub>\n                    <jats:bold>\n                      P\n                      <jats:sub>En<\/jats:sub>\n                    <\/jats:bold>\n                    exhibits exceptional efficacy in inducing cancer cell apoptosis and in vivo tumor ablation using low\u2010power NIR laser irradiation (0.3 W\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    , 808 nm) as well as excellent biological safety, underscoring its potential for advancing light\u2010induced cancer therapies.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202400885","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T11:54:10Z","timestamp":1712231650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Making the Brightest Ones Dim: Maximizing the Photothermal Conversion Efficiency of BODIPY\u2010Based Photothermal Agents"],"prefix":"10.1002","volume":"13","author":[{"given":"Gibeom","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Life Science Chung\u2010Ang University  84 Heukseok\u2010ro, Dongjak\u2010gu Seoul 06974 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myunghwan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bouffard","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Nanoscience Ewha Womans University  52 Ewhayeodae\u2010gil, Seodaemun\u2010gu Seoul 03760 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehyeon","family":"Bae","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chung\u2010Ang University  84 Heukseok\u2010ro, Dongjak\u2010gu Seoul 06974 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-8342","authenticated-orcid":false,"given":"Youngmi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae\u2010ro, Dongdaemun\u2010gu Seoul 02447 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1919.02610460001001"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.107.70102"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-009-0553-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3728"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01115"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2023.102361"},{"key":"e_1_2_8_3_4","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25128"},{"key":"e_1_2_8_3_5","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-022-00017-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00381"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC00785D"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00606"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00522A"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00618K"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0410-2"},{"key":"e_1_2_8_7_4","doi-asserted-by":"publisher","DOI":"10.1111\/php.13184"},{"key":"e_1_2_8_7_5","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00891"},{"key":"e_1_2_8_7_6","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202301138"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b00021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c13067"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c09071"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/131839b0"},{"key":"e_1_2_8_10_2","volume-title":"Principles and Applications of Photochemistry","author":"Wardle B.","year":"2009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000089"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.03.009"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC03173A"},{"key":"e_1_2_8_11_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214564"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05383"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201907093"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201907855"},{"key":"e_1_2_8_12_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c11701"},{"key":"e_1_2_8_12_5","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c09993"},{"key":"e_1_2_8_12_6","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107836"},{"key":"e_1_2_8_12_7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add5660"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00855B"},{"key":"e_1_2_8_13_2","volume":"35","author":"Cheng H.\u2010B.","year":"2023","journal-title":"Adv. Mater."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1840685"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00268977000100171"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3SC52495G"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201503040"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CP06799A"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.9b08292"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201304296"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5b02080"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00044-3"},{"key":"e_1_2_8_18_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2591"},{"key":"e_1_2_8_18_4","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR07849K"},{"key":"e_1_2_8_18_5","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00442C"},{"key":"e_1_2_8_18_6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_8_18_7","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR07627H"},{"key":"e_1_2_8_18_8","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB02491J"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111541"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp902962h"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0pp00306a"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn5062386"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/b822776d"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b00043"},{"key":"e_1_2_8_24_1","first-page":"1408","volume":"58","author":"Brown J. M.","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01719-5"},{"key":"e_1_2_8_24_3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.652266"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc704"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(03)00003-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2007.12.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsaem.8b02100"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac101329h"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.03.003"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202400885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:28:41Z","timestamp":1759768121000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202400885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":66,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/adhm.202400885"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202400885","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]},"assertion":[{"value":"2024-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400885"}}