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However, multiple injections and unsatisfied immune responses are the main obstacles for current vaccine application. Herein, a dynamic covalent hydrogel (DCH) is used as a single\u2010dose vaccine adjuvant for eliciting robust and sustained humoral immunity. By adjusting the mass ratio of the DCH gel, 10\u201330 d constant release of the loaded recombinant protein antigens is successfully realized, and it is proved that sustained release of antigens can significantly improve the vaccine efficacy. When loading SARS\u2010CoV\u20102 RBD (Wuhan and Omicron BA.1 strains) antigens into this DCH gel, an over 32\u00a0000 times and 8000 times improvement is observed in antigen\u2010specific antibody titers compared to conventional Aluminum adjuvanted vaccines. 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