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Effectively modifying bioactive motifs at the inner pore surface provides appropriate niches for cell\u2010scaffold interactions. A molecular imprinting method and sacrificial templates are introduced to prepare inner pore surface modification in the macroporous hydrogels. In detail, acrylated bisphosphonates (Ac\u2010BPs) chelating to templates (CaCO<jats:sub>3<\/jats:sub> particles) are anchored on the inner pore surface of the methacrylated gelatin (GelMA)\u2010methacrylated hyaluronic acid (HAMA)\u2010poly (ethylene glycol) diacrylate (PEGDA) macroporous hydrogel (GHP) to form a functional hydrogel scaffold (GHP\u2010<jats:italic>int<\/jats:italic>\u2010BP). GHP\u2010<jats:italic>int<\/jats:italic>\u2010BP, but not GHP, effectively crafts artificial cell niches to substantially alter cell fates, including osteogenic induction and osteoclastic inhibition, and promote in situ bone regeneration. These findings highlight that molecular imprinting on the inner pore surface in the hydrogel efficiently creates orthogonally additive bio\u2010instructive scaffolds for bone regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202400897","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T20:00:45Z","timestamp":1713297645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Molecularly Imprinted Macroporous Hydrogel Promotes Bone Regeneration via Osteogenic Induction and Osteoclastic Inhibition"],"prefix":"10.1002","volume":"13","author":[{"given":"Jingxiao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. 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