{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:24:43Z","timestamp":1791332683671,"version":"4.3.1"},"reference-count":47,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310031_197617\/1"],"award-info":[{"award-number":["310031_197617\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Wound infections pose a significant challenge in healthcare, and traditional antibiotic treatments often result in the development of resistant pathogens. Addressing this gap, ProGel is introduced, a living hydrogel created by entrapping probiotic\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    as a therapeutic component within a gelatin matrix. With a double\u2010syringe system, ProGel can be easily mixed and applied, conforming swiftly to any wound shape and forming hydrogel in situ. It also demonstrates robust mechanical and self\u2010healing properties owing to the Schiff\u2010base bonds. ProGel sustains more than 80% viability of the entrapped\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    while restricting their escape from the hydrogel. After a week of storage, more than 70% viability of the entrapped\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    is preserved. Importantly, ProGel exhibits broad\u2010spectrum antimicrobial efficacy against pathogens commonly associated with wound infections, i.e.,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (7Log reduction),\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (3\u20107Log reduction), and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (40\u201370% reduction). Moreover, its cytocompatibility is affirmed through coculture with human dermal fibroblasts. The effectiveness of ProGel is further highlighted in more clinically relevant tests on human skin wound models infected with\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , where it successfully prevents the biofilm formation of these pathogens. This study showcases an injectable living hydrogel system for the management of complex wound infections.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202400921","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:17:50Z","timestamp":1719397070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["An Injectable Living Hydrogel with Embedded Probiotics as a Novel Strategy for Combating Multifaceted Pathogen Wound Infections"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-5800","authenticated-orcid":false,"given":"Siyuan","family":"Tao","sequence":"first","affiliation":[{"name":"Laboratory for Biointerfaces Empa Swiss Federal Laboratories for Materials Science and Technology  St. Gallen 9014 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