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However, it remains a challenge to produce a single drug that can perform dual functions. Nitric oxide (NO), with its antibacterial and wound\u2010healing activities, is an ideal solution to address this challenge. However, many controlled\u2010release strategies for NO rely on external probes for tracing the release in situ, making it difficult to precisely assess the location and magnitude. To address this issue, this study describes a novel NO donor, DHU\u2010NO1, capable of efficiently releasing NO under mild conditions (450\u00a0nm illumination). Simultaneously, DHU\u2010NO1 generates the fluorophore Azure B (AZB), which enables direct, non\u2010consumptive tracing of the NO release by monitoring the fluorescence and absorption changes in AZB. Given that NO can be conveniently traced, the amount of released NO can be controlled during biological applications, thereby allowing both functions of NO to be performed. When applied to the affected area, DHU\u2010NO1, illuminated by both a simple light\u2010emitting diode (LED) light source and natural light, achieves significant antibacterial effects against wound infections and promotes wound healing in mice. This study offers a novel and effective approach for treating wound infections.<\/jats:p>","DOI":"10.1002\/adhm.202400922","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T05:29:00Z","timestamp":1716787740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design and Application of an In Situ Traceable Nitric Oxide\u00a0Donor for Promoting the Healing of Wound Infections"],"prefix":"10.1002","volume":"13","author":[{"given":"Shasha","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiexiang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative 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