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Immunosuppression and difficulties in accessing tumors with therapeutic agents are major obstacles for GBM treatments. Classical monocytes (CMs) possess the strongest infiltration among myeloid cells recruited into tumors during tumorigenesis. In this study, CMs are utilized to deliver the small\u2010molecule CUDC\u2010907 encapsulated in nanoparticles (907\u2010NPs@CMs) for GBM therapy. Hitchhiking on CMs enables more 907\u2010NPs to successfully penetrate the blood\u2013brain barrier (BBB) and reach the interior of tumors. Results demonstrate that 907\u2010NPs@CMs significantly improve the survival rates by suppressing tumor growth and reversing the immunosuppression of tumor microenvironment (TME). Furthermore, the high delivery efficiency of CMs reduces the amount of CUDC\u2010907 required for treatments, reducing the physiological toxicity and off\u2010target effects caused by high doses. 907\u2010NPs@CMs is a safe and versatile therapeutic system that provides a platform for targeted drug delivery to tumors and the ability to treat GBM through a combination of chemotherapy and immunotherapy.<\/jats:p>","DOI":"10.1002\/adhm.202400925","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:46:30Z","timestamp":1725014790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Classical Monocytes Shuttling for Precise Delivery of Nanotherapeutics to Glioblastoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Congwen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Fudan University  Shanghai 200032 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