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Resina draconis (RD), a natural resin traditionally used in powder form for wound care, is now considered unsuitable due to the lack of gas permeability and moist environment required for wound healing. Here, RD is incorporated in situ by constructing a 3D coiled fibrous scaffold with polycaprolactone\/polyethylene oxide. Due to the high porosity of 3D scaffold, the RD\u20103D dressings have a favorable swelling capacity, providing permeability and moisture for wound repair. Meanwhile, the transformation of RD powder into 3D dressings fully demonstrates capabilities of RD in rapid hemostasis, bactericidal, and inflammation\u2010regulating activities. In vivo evaluations using pressure ulcer and infected wound models confirm the high efficacy of RD\u20103D dressing in early wound healing, particularly beneficial in the infected wound model compared to recombinant bovine FGF\u2010basic. Further biological analysis shows that resveratrol, loureirin A, and loureirin B, as potentially bioactive components of RD, individually contribute to different aspects of wound healing. Collectively, RD\u20103D integrated dressings represent a simple, cost\u2010effective, and safe approach to wound healing, providing an alternative therapy for translating medical dressings from bench to bedside.<\/jats:p>","DOI":"10.1002\/adhm.202401105","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T17:10:33Z","timestamp":1718730633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transformation of Natural Resin Resina Draconis to 3D Functionalized Fibrous Scaffolds for Efficient Chronic Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Shijie","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"},{"name":"Guang'anmen Hospital China Academy of Chinese Medical Sciences  Beijing 100053 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-0738","authenticated-orcid":false,"given":"Ruodan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20692"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0329-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12443"},{"key":"e_1_2_9_6_1","first-page":"15","volume":"6","author":"J\u00e4rbrink K.","year":"2017","journal-title":"Syst. 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