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However, its water dispersibility, conductivity, and biocompatibility are incompatible, which limit its further development. In this work, biocompatible electrode material of PEDOT doped with sodium sulfonated alginate (SS) which contains two functional groups of sulfonic acid and carboxylic acid per repeat unit of the macromolecule. The as dual\u2010site doping strategy simultaneously boosts anticoagulant and electrochemical performances, for example, good hydrophilicity (water contact angle of 59.40\u00b0), well dispersibility (dispersion solution unstratified in 30 days), high conductivity (4.45 S m<jats:sup>\u22121<\/jats:sup>), and enhanced anticoagulant property (extended activated partial thrombin time value of 59.0 s), forming an adjustable PEDOT: biomacromolecule interface; this fills the technical gap of implantable bioelectronics in terms of coagulation and thrombosis risk. At the same time, the assembled all\u2010in\u2010one supercapacitor with anticoagulant properties is prepared by PEDOT: sodium sulfonated alginate as electrode material and sodium alginate hydrogel as electrolyte layer. The dual\u2010site doping strategy provides a new opinion for the design and optimization of functional conductive polymers and its applications in implantable energy storage fields.<\/jats:p>","DOI":"10.1002\/adhm.202401134","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T19:19:58Z","timestamp":1716319198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dual\u2010Site Biomacromolecule Doped Poly(3, 4\u2010Ethylenedioxythiophene) for Bosting Both Anticoagulant and Electrochemical Performances"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiangya","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Processing and Recycling of Non\u2010ferrous Metals School of Materials Science and Engineering Department of Polymeric Materials Engineering Lanzhou University of Technology  Lanzhou Gansu 730050 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