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Antifungal drugs used to treat these infections can be toxic and overuse contributes to growing antifungal resistance.\n                    <jats:italic>Candida<\/jats:italic>\n                    spp., particularly\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , are implicated in a majority of these infections. Virulent\n                    <jats:italic>C. albicans<\/jats:italic>\n                    produce secreted aspartic proteases (Saps) that aid in pathogen tissue invasion and proliferation at an infected site. Here, fungi\u2010responsive hydrogels are developed that degrade in the presence of Saps to provide a triggered release of encapsulated liposomal antifungals. The hydrogel backbone incorporates a Sap\u2010cleavable peptide sequence enabling Sap\u2010responsive degradation. Hydrogels are found to effectively degrade in the presence of Saps extracted from\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . Encapsulated liposomal antifungals show similar release kinetics as hydrogel degradation products in the presence of Saps, supporting a degradation\u2010dependent release mechanism. Antifungal liposome\u2010loaded responsive hydrogels exhibit successful eradication of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cultures and remain stable in sterile murine wound fluid. Finally, no significant cytotoxicity is observed for murine fibroblast cells and red blood cells exposed to hydrogel degradation products. These fungi\u2010responsive hydrogels have the potential to be used for local, on\u2010demand delivery of antifungal drugs, for effective treatment of fungal infections while helping to limit unnecessary exposure to these\u00a0therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202401157","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T02:14:45Z","timestamp":1724984085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Fungal Enzyme\u2010Responsive Hydrogel Drug Delivery Platform for Triggered Antifungal Release"],"prefix":"10.1002","volume":"13","author":[{"given":"Noel","family":"Vera\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"School Of Engineering Institute for Biology Engineering, and Medicine Brown University 184 Hope Street Providence RI 02912 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-3812","authenticated-orcid":false,"given":"Carly","family":"Deusenbery","sequence":"additional","affiliation":[{"name":"School Of Engineering Institute for Biology Engineering, and Medicine Brown University 184 Hope Street Providence RI 02912 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-8844","authenticated-orcid":false,"given":"Veronica","family":"LaMastro","sequence":"additional","affiliation":[{"name":"School Of Engineering Institute for Biology Engineering, and Medicine Brown University 184 Hope Street Providence RI 02912 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-7729","authenticated-orcid":false,"given":"Anita","family":"Shukla","sequence":"additional","affiliation":[{"name":"School Of Engineering Institute for Biology Engineering, and Medicine Brown University 184 Hope Street Providence RI 02912 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1057766"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2509.190168"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-020-00369-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00199"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.6.1526"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-023-00926-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.1.40"},{"key":"e_1_2_8_8_1","first-page":"295","volume":"7","author":"Gayas M. 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