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Multichannel NGCs have been widely studied to mimic the structure of natural nerve bundles. However, multichannel conduits are prone to structural instability. Thermo\u2010responsive shape memory polymers (SMPs) can maintain a persistent initial structure over the body temperature range. Electrical stimulation (ES), utilized within nerve NGCs, serves as a biological signal to expedite damaged nerve regeneration. Here, an electrospun shape\u2010persistent conductive NGC is designed to maintain the persistent tubular structure in the physiological temperature range and improve the conductivity. The physicochemical and biocompatibility of these P, P\/G, P\/G\u2010GO, and P\/G\u2010RGO NGCs are conducted in vitro. Meanwhile, to evaluate biocompatibility and peripheral nerve regeneration, NGCs are implanted in subcutaneous parts of the back of rats and sciatic nerves assessed by histology and immunofluorescence analyses. The conductive NGC displays a stable structure, good biocompatibility, and promoted nerve regeneration. Collectively, the shape\u2010persistent conductive NGC (P\/G\u2010RGO) is expected to promote peripheral nerve recovery, especially for long\u2010gap and large\u2010diameter nerves.<\/jats:p>","DOI":"10.1002\/adhm.202401160","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T08:24:58Z","timestamp":1715934298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Shape\u2010Persistent Conductive Nerve Guidance Conduits for Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiahui","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 P. R. 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