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If the behavior of immune cells is not well directed, chronic inflammation and foreign body reaction (FBR) will lead to scar formation and loss of biomaterial functionality. The immunologic response toward tissue repair or chronic inflammation after injury and implantation can be modulated by manipulating the surface properties of biomaterials. Tailoring surface properties of biomaterials enables the regulation of immune cell fate such as adhesion, proliferation, recruitment, polarization, and cytokine secretion profile. This review begins with an overview of the role of immune cells in tissue healing and their interactions with biomaterials. It then discusses how the surface properties of biomaterials influence immune cell behavior. The core focus is reviewing surface modification methods to create innovative materials that reduce foreign body reactions and enhance tissue repair and regeneration by modulating immune cell activities. The review concludes with insights into future advancements in surface modification techniques and the associated challenges.<\/jats:p>","DOI":"10.1002\/adhm.202401253","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:08:16Z","timestamp":1728259696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Immunomodulatory Biomaterials: Tailoring Surface Properties to Mitigate Foreign Body Reaction and Enhance Tissue Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Hamed","family":"Amani","sequence":"first","affiliation":[{"name":"Department of Medical Nanotechnology Faculty of Advanced Technologies in Medicine Iran University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8213","authenticated-orcid":false,"given":"Mahdieh","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences School of Dental Medicine University of Pittsburgh  Pittsburgh PA 15261 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Shahriari","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-3359","authenticated-orcid":false,"given":"Juan M","family":"Taboas","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences School of Dental Medicine University of Pittsburgh  Pittsburgh PA 15261 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)90247-7"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801000"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801660"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/791725"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.08.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801419"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-050014-0.50009-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700995"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00895"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2600"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2268-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35958"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/1\/1\/R01"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(200002)49:2<257::AID-JBM15>3.0.CO;2-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32971"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.055"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0391-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.12.006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.13"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007576"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM90063A"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v015a08"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900764"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010051"},{"key":"e_1_2_9_27_1","first-page":"71","volume-title":"Chasing the recipe for a pro\u2010regenerative immune system, Seminars in cell & developmental biology","author":"Godwin J. 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