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Due to these attributes, it finds applications in diverse fields like orthopedics, encompassing cervical disc replacement for the neck and spine, along with dentistry and plastic surgery. However, due to insufficient bonding with bone, various methods such as hydroxyapatite (HA) coating on the surface are attempted. Nonetheless, the interface between the polymer and ceramic, two different materials, tended to delaminate after transplantation, posing challenges in preventing implant escape or dislodgement. This research delves into the laser\u2010driven hydroxyapatite penetration\u2010synthesis technique. Differing from conventional coating methods that bond layers of dissimilar materials like HA and PEEK, this technology focuses on synthesizing and infiltrating ionized HA within the PEEK substrate resulting in an interface\u2010free HA\u2013PEEK surface. Conversely, HA\u2013PEEK with this technology applied achieves complete, gap\u2010free direct bone\u2013implant integration. \u00a0Our research involved the analysis of various aspects. By means of these, we quantitatively assesed the enhanced bone bonding characteristics of HA\u2010PEEK surfaces treated with this approach and offered and explanation for the mechanism responsible for direct bone integration.<\/jats:p>","DOI":"10.1002\/adhm.202401260","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:15:03Z","timestamp":1718957703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biomedical Device Surface Treatment by Laser\u2010Driven Hydroxyapatite Penetration\u2010Synthesis Technique for Gapless PEEK\u2010to\u2010Bone Integration"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8208-7805","authenticated-orcid":false,"given":"Seung\u2010Hoon","family":"Um","sequence":"first","affiliation":[{"name":"Biomaterials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST)  Seoul 02792 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