{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:36:07Z","timestamp":1790980567489,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["431232613 \u2013 SFB 1449"],"award-info":[{"award-number":["431232613 \u2013 SFB 1449"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infectious wounds occur when harmful microorganisms such as bacteria or viruses invade a wound site. Its problems associated include delayed healing, increased pain, swelling, and the potential for systemic infections. Therefore, developing new wound dressing materials with antibacterial effects is crucial for improving the healing process. Here a redox\u2010degradable hydrogel loaded with an antibacterial peptide (vancomycin) in a straightforward gram\u2010scale synthesis, is developed. The hydrogel structure consists of a disulfide bond\u2010containing hyperbranched polyglycerol (SS\u2010hPG) that is cross\u2010linked by 4\u2010arm polyethylene glycol\u2010thiol (4\u2010arm PEG\u2010SH). The polymerization mechanism and full characterization of SS\u2010hPG are described as this synthesis is reported for the first time. Rheology is used to ascertain the hydrogel's mechanical characteristics, such as stiffness, and self\u2010healing, determining these properties for different ratios and concentrations of both gel components. The incorporation of disulfide bonds in the hydrogel is proved by conducting degradation experiments in reductive environments. Fluorescein isothiocyanate\u2010albumin (FITC\u2010BSA) and vancomycin both are loaded into the gel, and the guest release kinetics is assessed for both slow and on\u2010demand releases. Finally, the in vitro and in vivo experiments prove that the vancomycin\u2010loaded hydrogel acts as an antibacterial barrier for wound dressing and accelerates the healing of infectious wounds in a mouse model.<\/jats:p>","DOI":"10.1002\/adhm.202401289","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T02:23:43Z","timestamp":1720491823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Redox\u2010Responsive Hydrogels Loaded with an Antibacterial Peptide as Controlled Drug Delivery for Healing Infectious Wounds"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-0860","authenticated-orcid":false,"given":"Mariam","family":"Cherri","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi S.","family":"Stergiou","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-9373","authenticated-orcid":false,"given":"Zainab","family":"Ahmadian","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Lorestan University of Medical Sciences  68151-44311 Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana L.","family":"Povolotsky","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boonya","family":"Thongrom","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-5080","authenticated-orcid":false,"given":"Ehsan","family":"Mohammadifar","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-162X","authenticated-orcid":false,"given":"Rainer","family":"Haag","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustr. 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.3c01137"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00950"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12557"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2009.03.006"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2007.11.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700786"},{"key":"e_1_2_8_4_1","first-page":"212","volume":"2","author":"Reichman D. 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V.Preuss F.Bernice inStatPearls StatPearls Publishing Copyright 2023 StatPearls Publishing LLC. Treasure Island (FL) ineligible companies. Disclosure: Charles Preuss declares no relevant financial relationships with ineligible companies. Disclosure: Fidelia Bernice declares no relevant financial relationships with ineligible companies 2023."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69058-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202200271"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820231007"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(02)00226-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.11.043"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202401289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202401289","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202401289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:39:51Z","timestamp":1773326391000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202401289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":36,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/adhm.202401289"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202401289","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2024-21qfw","asserted-by":"object"}]},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]},"assertion":[{"value":"2024-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401289"}}