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In this study, organic electrolytic photocapacitors (OEPC) are employed to\u00a0investigate the\u00a0effects of\u00a0light\u2010controlled electric stimulation on\u00a0neuronal networks in vitro and in vivo. The interactions between the devices and biological systems are characterized. Stimulation of primary rat cortical neurons results in an\u00a0elevated expression of c\u2010Fos within a mature neuronal network. OEPC implantation for three weeks and subsequent stimulation of the somatosensory cortex leads to an\u00a0increase of c\u2010Fos in neurons at the stimulation site and in connected brain\u00a0regions (entorhinal cortex, hippocampus), both in\u00a0the\u00a0ipsi\u2010 and\u00a0contralateral hemispheres. Reactivity of\u00a0glial and\u00a0immune cells after semi\u2010chronic implantation of OEPC in the rat brain is comparable to\u00a0that\u00a0of\u00a0surgical controls, indicating minimal foreign body response. 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These findings highlight its potential as a\u00a0novel mode of neurostimulation and instigate further exploration into applications in fundamental neuroscience.<\/jats:p>","DOI":"10.1002\/adhm.202401303","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T02:50:22Z","timestamp":1723603822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Light\u2010Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi\u2010Chronic Study in Cortical Cell Culture and Rat Model"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-8129","authenticated-orcid":false,"given":"Marta","family":"Nowakowska","sequence":"first","affiliation":[{"name":"Department of\u00a0Neurosurgery Medical University of\u00a0Graz  Auenbruggerplatz 29 Graz 8036 Austria"},{"name":"BioTechMed\u2010Graz  Mozartgasse 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