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However, current methodologies have not yet achieved the necessary low detection limits and efficient capture. Here, a novel polypyrrole nanotentacles sensing platform featuring anemone\u2010like structures capable of simultaneously detecting protein biomarkers and capturing CTCs is introduced. The incorporation of nanotentacles significantly enhances the electrode surface area, providing abundant active sites for antibody binding. This enhancement allows detecting nucleus matrix protein22 and bladder tumor antigen with 2.39 and 3.12 pg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    detection limit, respectively. Furthermore, the developed sensing platform effectively captures MCF\u20107 cells in blood samples with a detection limit of fewer than 10 cells mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , attributed to the synergistic multivalent binding facilitated by the specific recognition antibodies and the positive charge on the nanotentacles surface. This sensing platform demonstrates excellent detection capabilities and outstanding capture efficiency, offering a simple, accurate, and efficient strategy for early tumor detection.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202401305","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T07:19:03Z","timestamp":1716189543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sea Anemone\u2010Inspired Conducting Polymer Sensing Platform for Integrated Detection of Tumor Protein Marker and Circulating Tumor Cell"],"prefix":"10.1002","volume":"13","author":[{"given":"Jialuo","family":"Ai","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 P. R. 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