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To repair transected peripheral nerves with short distances, a rapid\u2010forming, robust adhesive chitosan hydrogel is prepared by synthesizing maleic and dopamine bi\u2010functionalized fungal\u2010sourced chitosan (DM) and subsequently photopolymerizing DM precursor solution. The hydrogel rapidly polymerized under UV light irradiation (\u22482 s) and possessed a strong adhesive strength (273.33 \u00b1 55.07\u00a0kPa), facilitating a fast bonding of nerve stump. Especially, its tailored degradation profile over 28 days supported both early gap bridging and subsequent nerve regeneration. Furthermore, deferoxamine (DFO), a pro\u2010angiogenic drug, is loaded into the hydrogel to reach sustainable release, accelerating axonal growth synergistically. A 3\u00a0mm long sciatic nerve defects model in rats is used to investigate the efficacy of DM@DFO hydrogel for repairing peripheral nerve defects. After 60 days, the DM@DFO hydrogel significantly outperformed conventional sutures and fibrin glue, improving motor and sensory recovery by reducing inflammation, inhibiting scar formation, and accelerating vascular regeneration within 14 days post\u2010repair. This work highlights the DM@DFO hydrogel as a promising tissue adhesive for effective short\u2010distance peripheral nerve repair.<\/jats:p>","DOI":"10.1002\/adhm.202401412","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T08:49:01Z","timestamp":1726217341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rapid Forming, Robust Adhesive Fungal\u2010Sourced Chitosan Hydrogels Loaded with Deferoxamine for Sutureless Short\u2010Gap Peripheral Nerve Repair"],"prefix":"10.1002","volume":"13","author":[{"given":"Qi","family":"Dong","sequence":"first","affiliation":[{"name":"State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile University  Wuhan 430073 P. R. 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