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In this study, a second near\u2010infrared (NIR\u2010II) semiconducting polymer with aggregation\u2010induced emission (AIE) properties, named PIDT\u2010TBT, is deliberately designed and synthesized. This proposes an AIE luminogen\u2010based sterilization strategy in synergy with a low concentration of sodium hypochlorite (NaClO). Water\u2010dispersible PIDT\u2010TBT nanoparticles (NPs) are prepared, demonstrating good biocompatibility, as well as photothermal and photodynamic properties. Subsequent antibacterial tests show that PIDT\u2010TBT NPs exhibit excellent bactericidal effects against three bacterial strains: <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Streptococcus mutans<\/jats:italic>, and <jats:italic>Enterococcus faecalis<\/jats:italic>, upon 808\u00a0nm laser irradiation. In synergy with a low concentration of NaClO (0.5%) solution, PIDT\u2010TBT NPs significantly improves the outcome of root canal treatment under 808\u00a0nm laser irradiation in a human extracted tooth root canal infection model. Additionally, it is found that PIDT\u2010TBT NPs combine with a low concentration of NaClO solution could safely dissolve dentin debris and further increase the efficiency of root canal preparation by altering the elemental composition of the inner root canal wall.<\/jats:p>","DOI":"10.1002\/adhm.202401434","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:09:11Z","timestamp":1724342951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Enhancing Root Canal Therapy with NIR\u2010II Semiconducting Polymer AIEgen and Low\u2010Concentration Sodium Hypochlorite Synergy"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuanzhu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of International VIP Dental Clinic Tianjin Stomatological Hospital School of Medicine Nankai University Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction  Tianjin 300041 P. 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