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Passive immunotherapies and biologic drugs targeting IL\u20101\u03b2, while offering significant clinical benefit, nevertheless have limitations such as significant non\u2010response rates, induction of anti\u2010drug antibodies, and high costs. Here, an active immunotherapy raising antibody responses against IL\u20101\u03b2 employing self\u2010assembling peptide nanofibers is described. The nanofibers contain defined quantities of B\u2010cell epitopes from IL\u20101\u03b2 and exogenous T helper epitopes and employ the Q11 self\u2010assembling peptide platform. Without adjuvant, the nanofibers raised durable anti\u2010IL\u20101\u03b2 antibody responses that inhibit IL\u20101\u03b2 activity in vitro and in vivo. In a mouse model of imiquimod\u2010induced psoriasis, prophylactic immunizations with the nanofibers diminished symptoms of epidermal thickening. This therapeutic effect is associated with biasing the immune response toward an anti\u2010inflammatory IgG1\/Th2 phenotype and a lowered expression of proinflammatory genes in the skin. Further, anti\u2010IL\u20101\u03b2 nanofibers induced therapeutic immunosuppressive CD62L+ Treg cells. This technology represents a potential alternative for passive immunotherapies and other biologics for treating chronic inflammatory conditions.<\/jats:p>","DOI":"10.1002\/adhm.202401444","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T01:37:38Z","timestamp":1723081058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL\u20101\u03b2\u2010Mediated Inflammation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-5225","authenticated-orcid":false,"given":"Shamitha","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Duke University  Durham NC 27705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of 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