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Herein, an innovative cascade\u2010amplified nanotheranostics based on biodegradable Pd\u2010BSA\u2010GOx nanocomposite for NIR\u2010II photoacoustic imaging (PAI) guides self\u2010enhanced NIR\u2010II PTT\/chemodynamic therapy (CDT)\/starvation synergistic therapy. The Pd\u2010BSA\u2010GOx demonstrates the ability to selectively convert overexpressed H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into strongly toxic \u00b7OH by a Pd\/Pd\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated Fenton\u2010like reaction at a lower pH level. Simultaneously, the GOx generates H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and gluconic acid, effectively disrupting nutrient supply and instigating tumor starvation therapy. More importantly, the heightened levels of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and increased acidity greatly enhance the Fenton\u2010like reactivity, generating a significant \u201c\u00b7OH storm,\u201d thereby achieving Pd\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated cascade\u2010amplifying CDT. The specific PTT facilitated by undegraded Pd accelerates the Fenton\u2010like reaction, establishing a positive feedback process for self\u2010enhancing synergetic PTT\/CDT\/starvation therapy via the NIR\u2010II guided\u2010PAI. Therefore, the multifunctional nanotheranostics presents a simple and versatile strategy for the precision diagnosis and treatment of tumors.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202401459","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:13:52Z","timestamp":1719033232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Biodegradable Cascade\u2010Amplified Nanotheranostics for Photoacoustic\u2010Guided Synergistic PTT\/CDT\/Starvation Antitumor in the NIR\u2010II Window"],"prefix":"10.1002","volume":"13","author":[{"given":"Weiwei","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Third Hospital of Shanxi Medical University Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Tongji Shanxi Hospital  Taiyuan 030032 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