{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:44:30Z","timestamp":1791564270019,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370425"],"award-info":[{"award-number":["82370425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010870","name":"Qingdao Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["21\u20101\u20104\u2010rkjk\u201012\u2010nsh"],"award-info":[{"award-number":["21\u20101\u20104\u2010rkjk\u201012\u2010nsh"]}],"id":[{"id":"10.13039\/501100010870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aortic dissection (AD) is a severe cardiovascular disease necessitating active therapeutic strategies for early intervention and prevention. Nucleic acid drugs, known for their potent molecule\u2010targeting therapeutic properties, offer potential for genetic suppression of AD. Piwi\u2010interacting RNAs, a class of small RNAs, hold promise for managing cardiovascular diseases. Limited research on these RNAs and AD exists. This study demonstrates that an antagomir targeting heart\u2010apoptosis\u2010associated piRNA (HAAPIR) effectively regulates vascular remodeling, mitigating AD occurrence and progression through the myocyte enhancer factor 2D (Mef2D) and matrix metallopeptidase 9 (MMP9) pathways. Green tea\u2010derived plant exosome\u2010like nanovesicles (PELNs) are used for oral administration of antagomir. The antagomir\u2010HAAPIR\u2010nanovesicle complex, after purification and optimization, exhibits a high packing rate, while the antagomir is resistant to enzyme digestion. Administered to mice, the complex targets the aortic lesion, reducing AD incidence and improving survival. Moreover, MMP9 and Mef2D expression decrease significantly, inhibiting the phenotypic conversion of human aortic smooth muscle cells. PELNs encapsulate the antagomir\u2010HAAPIR complex, maintaining stability, mediating transport into the bloodstream, and delivering Piwi\u2010interacting RNAs to AD sites. Thus, HAAPIR is a potential target for persistent clinical AD prevention and treatment, and nanovesicle\u2010encapsulated nucleic acids offer a promising cardiovascular disease treatment, providing insights for other therapeutic targets.<\/jats:p>","DOI":"10.1002\/adhm.202401466","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T07:01:26Z","timestamp":1722495686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Oral Piwi\u2010Interacting RNA Delivery Mediated by Green Tea\u2010Derived Exosome\u2010Like Nanovesicles for the Treatment of Aortic Dissection"],"prefix":"10.1002","volume":"13","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine The Affiliated Hospital of Qingdao University  No. 38 Dengzhou Road Qingdao 266021 P. R. 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