{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:37:36Z","timestamp":1791401856737,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22074057"],"award-info":[{"award-number":["22074057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21775059"],"award-info":[{"award-number":["21775059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["20YF3FA025"],"award-info":[{"award-number":["20YF3FA025"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["18YF1NA004"],"award-info":[{"award-number":["18YF1NA004"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Osteoarthritis (OA), characterized by chronic inflammation and cartilage degeneration, significantly affects over 500 million people globally. Nanoparticles have emerged as promising treatments for OA; however, current strategies often employ a single type of nanoparticle targeting specific disease stages, limiting sustained therapeutic efficacy. In this study, a novel collagen hydrogel is introduced, thiol crosslinked collagen\u2010cerium oxide\u2010poly(D,L\u2010lactic\u2010co\u2010glycolic acid) microspheres encapsulating nanoparticles (CSH\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010pFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    ), designed for the controlled release of cerium oxide (CeO\n                    <jats:sub>2<\/jats:sub>\n                    ) and ferric oxide (Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    ) nanoparticles for comprehensive OA management. The sulfhydryl cross\u2010linked collagen matrix embeds CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles and poly(D,L\u2010lactic\u2010co\u2010glycolic acid) (PLGA) microspheres encapsulating Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    nanoparticles. The CSH\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010pFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    hydrogel exhibits enhanced mechanical strength and remarkable injectability, along with a significant promotion of cell adhesion, proliferation, and chondrogenic differentiation. Notably, the hydrogel demonstrates intelligent responsiveness to high levels of reactive oxygen species, initiating the rapid release of CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles to address the intense inflammatory responses of early\u2010stage OA, followed by the sustained release of Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    nanoparticles to facilitate cartilage regeneration during the proliferative phase. In a rat model with cartilage defects, the hydrogel significantly alleviates inflammation and enhances cartilage regeneration, holding substantial potential for effectively managing the pathologically complex OA.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202401507","type":"journal-article","created":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:16:25Z","timestamp":1722125785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Xian","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 P. R. China"},{"name":"Gansu Engineering Research Center of Medical Collagen  Lanzhou 730000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0490-3783","authenticated-orcid":false,"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 P. R. China"},{"name":"Gansu Engineering Research Center of Medical Collagen  Lanzhou 730000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 P. R. China"},{"name":"Gansu Engineering Research Center of Medical Collagen  Lanzhou 730000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 P. R. China"},{"name":"Gansu Engineering Research Center of Medical Collagen  Lanzhou 730000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Lanzhou University Second Hospital  Lanzhou 730030 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-572X","authenticated-orcid":false,"given":"Jianxi","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 P. R. China"},{"name":"Gansu Engineering Research Center of Medical Collagen  Lanzhou 730000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02199-5"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13662"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.109904"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101992"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1232396"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/11762320701816966"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.06.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41594-y"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302833"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179137"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158236"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14061127"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.05.028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100864"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119821"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.718938"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302858"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15102509"},{"key":"e_1_2_9_14_3","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02199-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900099"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2021.100641"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2022.e00778"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202401507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:37:11Z","timestamp":1759790231000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202401507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":24,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/adhm.202401507"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202401507","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,27]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401507"}}