{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:24:50Z","timestamp":1790605490272,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M701082"],"award-info":[{"award-number":["2021M701082"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["242300420099"],"award-info":[{"award-number":["242300420099"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postoperative tumor recurrence and wound infection remain significant clinical challenges in surgery, often requiring adjuvant therapies. The combination treatment of photothermal therapy (PTT) and chemodynamic therapy (CDT) has proven to be effective in cancer treatment and wound infection. However, the hyperthermia during PTT increases the risk of normal tissue damage, severely impeding its application. Moreover, the efficacy of CDT is limited by insufficient hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) and excessive glutathione (GSH) levels at tumor or infection sites. Herein, an injectable and multifunctional CuO<jats:sub>2<\/jats:sub>@Au hydrogel system (CuO<jats:sub>2<\/jats:sub>@Au Gel) is developed for synergistic CDT and low\u2010temperature PTT (LTPTT) to prevent tumor recurrence and bacterial wound infections. CuO<jats:sub>2<\/jats:sub>@Au Gel is constructed by embedding therapeutic CuO<jats:sub>2<\/jats:sub>@Au into low\u2010melting point agarose hydrogel. In vitro and in vivo experiments confirm that the CuO<jats:sub>2<\/jats:sub>@Au in CuO<jats:sub>2<\/jats:sub>@Au Gel is capable of self\u2010supplying H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and depleting GSH, exhibiting effective CDT effect in acidic tumor or bacterial infected microenvironment. Additionally, it exhibits favorable photothermal conversion ability, inducing localized temperature elevation and synergistically enhancing CDT efficiency. The prepared CuO<jats:sub>2<\/jats:sub>@Au Gel demonstrates efficient tumor ablation capability in post\u2010surgery recurrence mouse models and exhibits promising anti\u2010infective efficiency in bacterial infection wound models, indicating significant potential in adjuvant therapy for post\u2010surgical treatment and recovery.<\/jats:p>","DOI":"10.1002\/adhm.202401551","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:43:44Z","timestamp":1719247424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Injectable Therapeutic Hydrogel with H<sub>2<\/sub>O<sub>2<\/sub> Self\u2010Supplying and GSH Consumption for Synergistic Chemodynamic\/Low\u2010Temperature Photothermal Inhibition of Postoperative Tumor Recurrence and Wound Infection"],"prefix":"10.1002","volume":"13","author":[{"given":"Peng","family":"Hu","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Life Sciences Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunpeng","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Life Sciences Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoye","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wujie","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Yu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"},{"name":"Institute of Materia Medica Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing 100050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-0530","authenticated-orcid":false,"given":"Jiahua","family":"Shi","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation State Key Laboratory of Antiviral Drugs Henan University  Kaifeng Henan 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21754"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32381-3"},{"key":"e_1_2_9_1_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0111-2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32160-z"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104578"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2020.04.022"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133596"},{"key":"e_1_2_9_3_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.08.057"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200681"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.012"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0410-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.135476"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101402"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01536-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.11.024"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305140"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001059"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.11.066"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03971"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214330"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.01.036"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101633"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.34133\/2021\/9816594"},{"key":"e_1_2_9_10_4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202360"},{"key":"e_1_2_9_10_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.08.023"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05991"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201804634"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-023-2536-1"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202103303"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03457"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.10.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.027"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.100765"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202206554"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101320"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121289"},{"key":"e_1_2_9_17_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.07.154"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07893"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12873"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300516"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202200178"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201907954"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101091"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c04031"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.146092"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.014"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b01401"},{"key":"e_1_2_9_26_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00204"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.015"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.5b01401"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202401551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:59:33Z","timestamp":1759773573000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202401551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":52,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/adhm.202401551"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202401551","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401551"}}