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A novel therapeutic approach is introduced using copper\u2010containing layered double hydroxides (Cu\u2010LDH) nanozymes integrated with nitric oxide\u2010releasing molecules (GSHNO), forming Cu\u2010LDH@GSHNO aimed at combating oxidative stress within the retinal vascular system. Combination of synthetic chemistry and biological testing, Cu\u2010LDH@GSHNO are synthesized, characterized, and assessed for curative effect in HUVECs and an oxygen\u2010induced retinopathy (OIR) mouse model. The results indicate that Cu\u2010LDH@GSHNO demonstrates SOD\u2010CAT cascade catalytic ability, accompanied with GSH and nitric oxide\u2010releasing capabilities, which significantly reduces oxidative cell damage and restores vascular function, presenting a dual\u2010function strategy that enhances treatment efficacy and safety for retinal vascular diseases. The findings encourage further development and clinical exploration of nanozyme\u2010based therapies, promising a new horizon in therapeutic approaches for managing retinal diseases driven by oxidative stress.<\/jats:p>","DOI":"10.1002\/adhm.202401600","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T05:36:43Z","timestamp":1721108203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cu\u2010Doping Layered Double Hydroxides Nanozyme Integrated with Nitric Oxide Donor for Enhanced Antioxidant Therapy in Retinopathy"],"prefix":"10.1002","volume":"13","author":[{"given":"Bai","family":"Xue","sequence":"first","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan, School of Basic Medical Sciences Zhengzhou University  Zhengzhou Henan 450001 China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou Henan 451163 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