{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:17:52Z","timestamp":1785237472351,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["KY2023QN0014"],"award-info":[{"award-number":["KY2023QN0014"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ferrous ion accumulation and lethal oxidative stress mediate irreversible retinal pigment epithelial (RPE) cell ferroptosis and subsequent photoreceptor degeneration, a potential key pathogenic factor in the onset of dry age\u2010related macular degeneration (dAMD), causing irreversible vision loss in the global elderly population. However, currently, no effective interventional treatment strategy exists in clinical practice. Herein, lesion site\u2010targeted melanin\u2010like nanoparticles, named ConA\u2010MelNPs, are designed as a novel ferroptosis inhibitor for retinal degenerative diseases. ConA\u2010MelNPs possessed chelating iron ion characteristics, alleviating severe mitochondrial damage caused by oxidative stress and protecting RPE cells from ferroptosis induced by sodium iodate (NaIO<jats:sub>3<\/jats:sub>). In a preclinical dAMD mouse model, a single intravitreal injection of ConA\u2010MelNPs yielded significant responses in electroretinograms and visually\u2010driven optomotor responses in visually impaired mice, resisting the challenge posed by secondary NaIO<jats:sub>3<\/jats:sub>\u2010induced injuries, with the long\u2010term sustainability of its therapeutic effect. Mechanistically, ConA\u2010MelNPs achieve a therapeutic effect by interrupting the detrimental cascade involving \u201cRPE cell ferroptosis, lethal oxidative stress, and microglial proinflammatory activation,\u201d affording the restoration of retinal homeostasis. The synthesized ConA\u2010MelNPs demonstrated good biosafety, with no detected ophthalmic or systemic side effects. Collectively, ConA\u2010MelNPs are proposed as a promising therapeutic option for atrophic retinal diseases such as dAMD.<\/jats:p>","DOI":"10.1002\/adhm.202401613","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T02:35:04Z","timestamp":1723430104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Melanin\u2010Like Nanomedicine Functions as a Novel RPE Ferroptosis Inhibitor to Ameliorate Retinal Degeneration and Visual Impairment in Dry Age\u2010Related Macular Degeneration"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2112-8521","authenticated-orcid":false,"given":"Keke","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Southwest Hospital The Third Military Medical University (Army Medical University)  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical Research Center The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0999-1950","authenticated-orcid":false,"given":"Zhiqing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second People's Hospital of Chengdu The Affiliated Hospital of Chengdu Medical College  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02609-5"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30489-7"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13580"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-318452"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00265-2"},{"key":"e_1_2_8_6_1","first-page":"10","author":"Nashine S.","year":"2021","journal-title":"Cells"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1009599"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0912"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.08.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015779"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166969"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5215"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111502"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06081"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.09.044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04022"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c18061"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01602C"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR00838H"},{"key":"e_1_2_8_15_1","first-page":"8","volume":"20","author":"Bridges C. D.","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.038"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-19728-4"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03520-2"},{"key":"e_1_2_8_16_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05121-z"},{"key":"e_1_2_8_16_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04924-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101971"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110078"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11262-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.027"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21841-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16059"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112955"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.04.003"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110153"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101502"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-75402-4_2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.863158"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-023-00358-4"},{"key":"e_1_2_8_28_2","first-page":"1132","volume":"15","author":"Zhao N.","year":"2023","journal-title":"Aging Dis."},{"key":"e_1_2_8_29_1","first-page":"221","author":"Yu C.","year":"2024","journal-title":"J. Exp. Med."},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05735-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02614-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109549"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109728"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051217"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37025-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09087"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.1887900"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.103920"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1234824"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2062887"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.2741\/3804"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030705"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02621-9"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040112"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-02030-1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207335"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.006"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202401613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:55:24Z","timestamp":1759751724000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202401613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":60,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/adhm.202401613"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202401613","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]},"assertion":[{"value":"2024-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401613"}}