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OCNs, derived from harsh acid oxidation of single\u2010wall carbon nanotubes or activated charcoal are previously shown to possess multiple nanozymatic activities including mimicking superoxide dismutase and catalyzing the oxidation of reduced nicotinamide adenine dinucleotide (NADH) to NAD\n                    <jats:sup>+<\/jats:sup>\n                    . These actions are predicted to generate a glycolytic shift and enhance mitochondrial energetics under impaired conditions. Impaired mitochondrial energy metabolism is increasingly recognized as an important facet of traumatic brain injury (TBI) pathophysiology and decreases the efficiency of electron transport chain (ETC)\u2010coupled adenosine triphosphate (ATP) and NAD\n                    <jats:sup>+<\/jats:sup>\n                    regeneration. In vitro, OCNs promote a pro\u2010aerobic shift in energy metabolism that persists through ETC inhibition and enhances glycolytic flux, glycolytic ATP production, and cellular generation of lactate, a crucial auxiliary substrate for energy metabolism. To address specific mechanisms of iron injury from hemorrhage, OCNs with the iron chelator, deferoxamine (DEF), covalently\u2010linked were synthesized. DEF\u2010linked OCNs induce a glycolytic shift\u00a0in\u2010vitro\u00a0and\u00a0in\u2010vivo\u00a0in tissue sections from a rat model of TBI complicated by hemorrhagic contusion. OCNs further reduced hemorrhage volumes 3 days following TBI. These results suggest OCNs are promising as pleiotropic mediators of cell and tissue resilience to injury.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202401629","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T08:07:25Z","timestamp":1727424445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-5727","authenticated-orcid":false,"given":"Karthik","family":"Mouli","sequence":"first","affiliation":[{"name":"Center for Genomics and Precision Medicine Department of Translational Medicine Institute of Biosciences and Technology Texas A&amp;M Health Science Center  Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-2159","authenticated-orcid":false,"given":"Anton V.","family":"Liopo","sequence":"additional","affiliation":[{"name":"Center for Genomics and Precision Medicine Department of Translational Medicine Institute of Biosciences and Technology Texas A&amp;M Health Science Center  Houston TX 77030 USA"},{"name":"Department of Chemistry Rice University  Houston TX 77005 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Rice University  Houston TX 77005 USA"},{"name":"Smalley\u2010Curl Institute Rice University  Houston TX 77005 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-0507","authenticated-orcid":false,"given":"Erica","family":"Underwood","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy The University of TX McGovern Medical School  Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy The University of TX McGovern Medical School  Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-7242","authenticated-orcid":false,"given":"Pramod K.","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy The University of TX McGovern Medical School  Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh T. 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